A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant
Hypercalcemia is an uncommon finding in children. Hypercalcemia has various etiologies including parathyroid dependent and independent mechanisms. Increased activity of the 1-alpha-hydroxylase enzyme in granulomatous diseases is a well-defined but an extremely rare cause of hypercalcemia in pediatri...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/4270852 |
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| _version_ | 1850224262724452352 |
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| author | Ambreen Sonawalla Vildan Tas Manish Raisingani Emir Tas |
| author_facet | Ambreen Sonawalla Vildan Tas Manish Raisingani Emir Tas |
| author_sort | Ambreen Sonawalla |
| collection | DOAJ |
| description | Hypercalcemia is an uncommon finding in children. Hypercalcemia has various etiologies including parathyroid dependent and independent mechanisms. Increased activity of the 1-alpha-hydroxylase enzyme in granulomatous diseases is a well-defined but an extremely rare cause of hypercalcemia in pediatric patients, particularly in infants. We describe the case of an infant who presented with failure to thrive, hepatosplenomegaly, and hypercalcemia who was initially treated with steroids but was later diagnosed with disseminated histoplasmosis in the absence of an underlying immunodeficiency. Extra caution should be used before considering steroids for the treatment of hypercalcemia and, whenever possible, steroids should not be initiated until a definite etiology is identified. |
| format | Article |
| id | doaj-art-51d6d6eaace749c080c9c31b43c26df7 |
| institution | OA Journals |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-51d6d6eaace749c080c9c31b43c26df72025-08-20T02:05:41ZengWileyCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/42708524270852A Rare and Potentially Fatal Etiology of Hypercalcemia in an InfantAmbreen Sonawalla0Vildan Tas1Manish Raisingani2Emir Tas3Pediatric Residency Program, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Pediatrics, Division of Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Pediatrics, Division of Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Little Rock, AR, USAHypercalcemia is an uncommon finding in children. Hypercalcemia has various etiologies including parathyroid dependent and independent mechanisms. Increased activity of the 1-alpha-hydroxylase enzyme in granulomatous diseases is a well-defined but an extremely rare cause of hypercalcemia in pediatric patients, particularly in infants. We describe the case of an infant who presented with failure to thrive, hepatosplenomegaly, and hypercalcemia who was initially treated with steroids but was later diagnosed with disseminated histoplasmosis in the absence of an underlying immunodeficiency. Extra caution should be used before considering steroids for the treatment of hypercalcemia and, whenever possible, steroids should not be initiated until a definite etiology is identified.http://dx.doi.org/10.1155/2019/4270852 |
| spellingShingle | Ambreen Sonawalla Vildan Tas Manish Raisingani Emir Tas A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant Case Reports in Endocrinology |
| title | A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant |
| title_full | A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant |
| title_fullStr | A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant |
| title_full_unstemmed | A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant |
| title_short | A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant |
| title_sort | rare and potentially fatal etiology of hypercalcemia in an infant |
| url | http://dx.doi.org/10.1155/2019/4270852 |
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