Effects of switching from dipeptidyl peptidase 4 inhibitors to oral semaglutide on oxidative stress and glycemic variability in patients with type 2 diabetes: an open-label, prospective, randomized, multicenter, parallel-group comparison study

Effects of switching from dipeptidyl peptidase 4 inhibitors to oral semaglutide on oxidative stress and glycemic variability in patients with type 2 diabetes: an open-label, prospective, randomized, multicenter, parallel-group comparison study

Abstract Background To compare the effects of switching from dipeptidyl peptidase 4 (DPP-4) inhibitors to oral semaglutide on oxidative stress and glucose variability assessed by continuous glucose monitoring in patients with type 2 diabetes mellitus (T2DM). Methods This was an open-label, prospecti...

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Main Authors: Makoto Ohara, Hiroki Yokoyama, Hiroaki Seino, Tomoki Fujikawa, Yo Kohata, Noriyuki Takahashi, Shunichiro Irie, Michishige Terasaki, Yusaku Mori, Tomoyasu Fukui, Sho-ichi Yamagishi
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Continuous glucose monitoring
Glucose variability
Oxidative stress
Type 2 diabetes mellitus
Glucagon-like peptide-1 receptor agonists
Dipeptidyl peptidase 4 inhibitor
Online Access:https://doi.org/10.1186/s13098-025-01691-y
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