The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats
Background: Deposition of amyloid beta (Aβ) in the brain triggers Alzheimer's disease. The aim of the present study was to investigate the effect of moderate-intensity interval training the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in...
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Iran Air Force Health Administration
2020-12-01
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| Series: | فصلنامه ابن سینا |
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| Online Access: | http://ebnesina.ajaums.ac.ir/article-1-925-en.pdf |
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| author | Mostafa Zarin Afzal Yaser Kazemzadeh Saeed Sedaghati Sanaz Mirzayan Abdolali Banaeifar |
| author_facet | Mostafa Zarin Afzal Yaser Kazemzadeh Saeed Sedaghati Sanaz Mirzayan Abdolali Banaeifar |
| author_sort | Mostafa Zarin Afzal |
| collection | DOAJ |
| description | Background: Deposition of amyloid beta (Aβ) in the brain triggers Alzheimer's disease. The aim of the present study was to investigate the effect of moderate-intensity interval training the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer's rats.
Materials and methods: For this purpose, 30 eight-week-old Wistar rats with an average weight of 191±10 g were randomly divided into three equal groups: Aβ+exercise, Aβ, and the control group. The rats of the first and second groups became Alzheimer's by injecting Aβ1-42 into the intraventricular space. After three days of recovery, the Aβ+exercise group experienced moderate-intensity intermittent aerobic exercise for four weeks. The other groups continued their normal lives.
Results: The results of one-way analysis of variance showed that there was a significant difference between the average levels of hippocampal Aβ, plasma Aβ, and plasma LRP1 in different groups (p=0.001). Also, the results of LSD post hoc test showed the greatest difference between the mean of Aβ+exercise group and Aβ group in the above variables.
Conclusion: In summary, the results of the present study indicated that the moderate-intensity interval training can increase the plasma levels of LRP1 and environmental clearance of Aβ levels in the hippocampus, resulting in the modulation and control of factors affecting Alzheimer's disease in laboratory rats. |
| format | Article |
| id | doaj-art-51d2aa7d6724464db6daa54dc24adb00 |
| institution | OA Journals |
| issn | 1735-9503 2645-4653 |
| language | fas |
| publishDate | 2020-12-01 |
| publisher | Iran Air Force Health Administration |
| record_format | Article |
| series | فصلنامه ابن سینا |
| spelling | doaj-art-51d2aa7d6724464db6daa54dc24adb002025-08-20T01:58:08ZfasIran Air Force Health Administrationفصلنامه ابن سینا1735-95032645-46532020-12-012242128The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s ratsMostafa Zarin Afzal0Yaser Kazemzadeh1Saeed Sedaghati2Sanaz Mirzayan3Abdolali Banaeifar4 Islamshahr Branch, Islamic Azad University, Tehran, Iran, Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran Islamshahr Branch, Islamic Azad University, Tehran, Iran Azad University, Tehran Jonoub Branch, Islamic Azad University, Tehran, Iran Background: Deposition of amyloid beta (Aβ) in the brain triggers Alzheimer's disease. The aim of the present study was to investigate the effect of moderate-intensity interval training the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer's rats. Materials and methods: For this purpose, 30 eight-week-old Wistar rats with an average weight of 191±10 g were randomly divided into three equal groups: Aβ+exercise, Aβ, and the control group. The rats of the first and second groups became Alzheimer's by injecting Aβ1-42 into the intraventricular space. After three days of recovery, the Aβ+exercise group experienced moderate-intensity intermittent aerobic exercise for four weeks. The other groups continued their normal lives. Results: The results of one-way analysis of variance showed that there was a significant difference between the average levels of hippocampal Aβ, plasma Aβ, and plasma LRP1 in different groups (p=0.001). Also, the results of LSD post hoc test showed the greatest difference between the mean of Aβ+exercise group and Aβ group in the above variables. Conclusion: In summary, the results of the present study indicated that the moderate-intensity interval training can increase the plasma levels of LRP1 and environmental clearance of Aβ levels in the hippocampus, resulting in the modulation and control of factors affecting Alzheimer's disease in laboratory rats.http://ebnesina.ajaums.ac.ir/article-1-925-en.pdfaerobic exercisealzheimer's diseasebeta amyloidlrp1 protein/human |
| spellingShingle | Mostafa Zarin Afzal Yaser Kazemzadeh Saeed Sedaghati Sanaz Mirzayan Abdolali Banaeifar The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats فصلنامه ابن سینا aerobic exercise alzheimer's disease beta amyloid lrp1 protein/human |
| title | The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats |
| title_full | The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats |
| title_fullStr | The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats |
| title_full_unstemmed | The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats |
| title_short | The effect of a moderate-intensity interval training on the plasma levels of LDL receptor-related protein-1 (LRP1) and cerebral and plasma levels of amyloid beta in induced Alzheimer\'s rats |
| title_sort | effect of a moderate intensity interval training on the plasma levels of ldl receptor related protein 1 lrp1 and cerebral and plasma levels of amyloid beta in induced alzheimer s rats |
| topic | aerobic exercise alzheimer's disease beta amyloid lrp1 protein/human |
| url | http://ebnesina.ajaums.ac.ir/article-1-925-en.pdf |
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