Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats

Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats

Abstract Background Lithium is extensively used for mood stabilization in bipolar disorder, but its long-term use can lead to nephrotoxicity, characterized by a reduction in glomerular filtration rate (GFR) and potential progression to end-stage renal disease (ESRD). Exercise has been shown to have...

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Bibliographic Details
Main Authors: Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Nephrology
Subjects:
Lithium-induced nephropathy
Endurance training
Exercise intensity
Glomerular filtration rate
Inflammation
Aquaporin 2
Online Access:https://doi.org/10.1186/s12882-025-03997-5
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