Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study
Abstract Background Infertility affects a significant portion of the global population, with male factor infertility contributing to nearly half of all cases. The success of assisted reproductive technologies (ART), such as in vitro fertilization (IVF), depends on selecting high-quality sperm with o...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-025-01424-w |
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| author | Yulia Michailov Eden Amsalem Natalia Umanski Valeria Tamadaev Shevach Friedler Bozhena Saar-Ryss |
| author_facet | Yulia Michailov Eden Amsalem Natalia Umanski Valeria Tamadaev Shevach Friedler Bozhena Saar-Ryss |
| author_sort | Yulia Michailov |
| collection | DOAJ |
| description | Abstract Background Infertility affects a significant portion of the global population, with male factor infertility contributing to nearly half of all cases. The success of assisted reproductive technologies (ART), such as in vitro fertilization (IVF), depends on selecting high-quality sperm with optimal motility, morphology, and DNA integrity. The Q300™ device offers a novel approach for improving sperm selection. Utilizing an advanced optical imaging system, the Q300™ isolates the morphologically compliant sperm cells sperm for injection into the oocytes. This study aims to assess the usability and preliminary clinical outcome of the Q300™ device under “real-life conditions” in a fertility laboratory setting. Methods Preliminary clinical data collected from Barzilai Medical Center with or without using the technology were compared to the Key Performance Indicators (KPI) for ART laboratories according to the Vienna Consensus. Results The data suggest that the Q300™ significantly improved day-3 embryo development, blastulation, and cumulative pregnancy rates. Conclusions By offering a more refined and efficient selection process, the Q300™ has the potential to redefine clinical practice in infertility treatment, providing patients with a higher likelihood of achieving successful outcomes. Trial registration NCT06232720. Date of registration: 15 February 2023. Enrollment of first subject: 20 August 2023. For more information, visit: https://clinicaltrials.gov/study/NCT06232720 . |
| format | Article |
| id | doaj-art-51ce775cf3194d2995a23f936e29f8cb |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-51ce775cf3194d2995a23f936e29f8cb2025-08-20T03:45:33ZengBMCReproductive Biology and Endocrinology1477-78272025-06-012311810.1186/s12958-025-01424-wClinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized studyYulia Michailov0Eden Amsalem1Natalia Umanski2Valeria Tamadaev3Shevach Friedler4Bozhena Saar-Ryss5Ben Gurion University of the Negev, Faculty of Health SciencesIVF Unit-Obstetrics and Gynecology Department, Barzilai Medical CenterIVF Unit-Obstetrics and Gynecology Department, Barzilai Medical CenterIVF Unit-Obstetrics and Gynecology Department, Barzilai Medical CenterBen Gurion University of the Negev, Faculty of Health SciencesBen Gurion University of the Negev, Faculty of Health SciencesAbstract Background Infertility affects a significant portion of the global population, with male factor infertility contributing to nearly half of all cases. The success of assisted reproductive technologies (ART), such as in vitro fertilization (IVF), depends on selecting high-quality sperm with optimal motility, morphology, and DNA integrity. The Q300™ device offers a novel approach for improving sperm selection. Utilizing an advanced optical imaging system, the Q300™ isolates the morphologically compliant sperm cells sperm for injection into the oocytes. This study aims to assess the usability and preliminary clinical outcome of the Q300™ device under “real-life conditions” in a fertility laboratory setting. Methods Preliminary clinical data collected from Barzilai Medical Center with or without using the technology were compared to the Key Performance Indicators (KPI) for ART laboratories according to the Vienna Consensus. Results The data suggest that the Q300™ significantly improved day-3 embryo development, blastulation, and cumulative pregnancy rates. Conclusions By offering a more refined and efficient selection process, the Q300™ has the potential to redefine clinical practice in infertility treatment, providing patients with a higher likelihood of achieving successful outcomes. Trial registration NCT06232720. Date of registration: 15 February 2023. Enrollment of first subject: 20 August 2023. For more information, visit: https://clinicaltrials.gov/study/NCT06232720 .https://doi.org/10.1186/s12958-025-01424-wARTOTASperm selectionICSIBlastocyst |
| spellingShingle | Yulia Michailov Eden Amsalem Natalia Umanski Valeria Tamadaev Shevach Friedler Bozhena Saar-Ryss Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study Reproductive Biology and Endocrinology ART OTA Sperm selection ICSI Blastocyst |
| title | Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study |
| title_full | Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study |
| title_fullStr | Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study |
| title_full_unstemmed | Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study |
| title_short | Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study |
| title_sort | clinical outcome using the q300™ device in a reproductive laboratory environment an open label non controlled and non randomized study |
| topic | ART OTA Sperm selection ICSI Blastocyst |
| url | https://doi.org/10.1186/s12958-025-01424-w |
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