A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters
ABSTRACT Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract. Case Presentation A 51‐year‐old Japanese woman with IC/HL developed bilateral u...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.70010 |
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| author | Satoki Otsuka Yoshiyuki Akiyama Daichi Maeda Aya Niimi Kenichi Hashimoto Jun Kamei Satoru Taguchi Yuta Yamada Yusuke Sato Daisuke Yamada Tomonori Minagawa Tetsuo Ushiku Yukio Homma Haruki Kume |
| author_facet | Satoki Otsuka Yoshiyuki Akiyama Daichi Maeda Aya Niimi Kenichi Hashimoto Jun Kamei Satoru Taguchi Yuta Yamada Yusuke Sato Daisuke Yamada Tomonori Minagawa Tetsuo Ushiku Yukio Homma Haruki Kume |
| author_sort | Satoki Otsuka |
| collection | DOAJ |
| description | ABSTRACT Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract. Case Presentation A 51‐year‐old Japanese woman with IC/HL developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence of bilateral vesicoureteral reflux or bladder deformity. Ureteroscopy showed severe ureteral stenosis due to mucosal hyperplasia at the mid/upper levels of both ureters, leading to the insertion of bilateral ureteral stents. Histological examination of the ureteral lesions showed similar chronic inflammatory changes to the bladder lesions, which were compatible with IC/HL. Bilateral ureteral stenosis persisted after a two‐year corticosteroid treatment (prednisolone, 7.5 mg/day), while IC/HL symptoms have disappeared. Conclusion IC/HL could involve the upper ureters, and thus regular follow‐up imaging of upper urinary tracts in patients with IC/HL is warranted. |
| format | Article |
| id | doaj-art-51c1ea70ce2b46cab200b2f376f7d5c5 |
| institution | Kabale University |
| issn | 2577-171X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj-art-51c1ea70ce2b46cab200b2f376f7d5c52025-08-20T03:32:50ZengWileyIJU Case Reports2577-171X2025-07-018431031410.1002/iju5.70010A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral UretersSatoki Otsuka0Yoshiyuki Akiyama1Daichi Maeda2Aya Niimi3Kenichi Hashimoto4Jun Kamei5Satoru Taguchi6Yuta Yamada7Yusuke Sato8Daisuke Yamada9Tomonori Minagawa10Tetsuo Ushiku11Yukio Homma12Haruki Kume13Department of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University Kanazawa JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Urology Shinshu University School of Medicine Nagano JapanDepartment of Pathology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Interstitial Cystitis Medicine Kyorin University School of Medicine Tokyo JapanDepartment of Urology, Graduate School of Medicine The University of Tokyo Tokyo JapanABSTRACT Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract. Case Presentation A 51‐year‐old Japanese woman with IC/HL developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence of bilateral vesicoureteral reflux or bladder deformity. Ureteroscopy showed severe ureteral stenosis due to mucosal hyperplasia at the mid/upper levels of both ureters, leading to the insertion of bilateral ureteral stents. Histological examination of the ureteral lesions showed similar chronic inflammatory changes to the bladder lesions, which were compatible with IC/HL. Bilateral ureteral stenosis persisted after a two‐year corticosteroid treatment (prednisolone, 7.5 mg/day), while IC/HL symptoms have disappeared. Conclusion IC/HL could involve the upper ureters, and thus regular follow‐up imaging of upper urinary tracts in patients with IC/HL is warranted.https://doi.org/10.1002/iju5.70010bladder pain syndromeHunnerhydronephrosisIC/BPSinterstitial cystitisstenosis |
| spellingShingle | Satoki Otsuka Yoshiyuki Akiyama Daichi Maeda Aya Niimi Kenichi Hashimoto Jun Kamei Satoru Taguchi Yuta Yamada Yusuke Sato Daisuke Yamada Tomonori Minagawa Tetsuo Ushiku Yukio Homma Haruki Kume A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters IJU Case Reports bladder pain syndrome Hunner hydronephrosis IC/BPS interstitial cystitis stenosis |
| title | A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters |
| title_full | A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters |
| title_fullStr | A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters |
| title_full_unstemmed | A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters |
| title_short | A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters |
| title_sort | case of interstitial cystitis with hunner lesions involving bilateral ureters |
| topic | bladder pain syndrome Hunner hydronephrosis IC/BPS interstitial cystitis stenosis |
| url | https://doi.org/10.1002/iju5.70010 |
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