Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity
Cutaneous small vessel vasculitis (CSVV) could be due to varied etiologies of which drug induced CSVV is a prime cause. It commonly presents as purpura but necrotizing lesions can be an uncommon presentation of the disease. Aromatase inhibitors like letrozole are newer drugs used in the management o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Clinical Dermatology Review |
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| Online Access: | https://journals.lww.com/10.4103/cdr.cdr_44_24 |
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| author | Liza Mohapatra Soumya Surath Panda Manoj Kumar Nayak Kallolinee Samal |
| author_facet | Liza Mohapatra Soumya Surath Panda Manoj Kumar Nayak Kallolinee Samal |
| author_sort | Liza Mohapatra |
| collection | DOAJ |
| description | Cutaneous small vessel vasculitis (CSVV) could be due to varied etiologies of which drug induced CSVV is a prime cause. It commonly presents as purpura but necrotizing lesions can be an uncommon presentation of the disease. Aromatase inhibitors like letrozole are newer drugs used in the management of breast carcinoma. There have been few reports of drug induced vasculitis secondary to letrozole. Herein, we report a case presenting with multiple purpura with ulcers and hemopurulent discharge over bilateral legs after letrozole intake for breast carcinoma. Patient was diagnosed with necrotizing CSVV due to letrozole based on history and clinico-histopathological correlation. To the best of our knowledge, this is the first report of letrozole induced necrotizing CSVV from India. |
| format | Article |
| id | doaj-art-51c183e775634e409f59cb4d824cfeda |
| institution | OA Journals |
| issn | 2542-551X 2542-5528 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj-art-51c183e775634e409f59cb4d824cfeda2025-08-20T02:17:59ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282024-10-018435435610.4103/cdr.cdr_44_24Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare EntityLiza MohapatraSoumya Surath PandaManoj Kumar NayakKallolinee SamalCutaneous small vessel vasculitis (CSVV) could be due to varied etiologies of which drug induced CSVV is a prime cause. It commonly presents as purpura but necrotizing lesions can be an uncommon presentation of the disease. Aromatase inhibitors like letrozole are newer drugs used in the management of breast carcinoma. There have been few reports of drug induced vasculitis secondary to letrozole. Herein, we report a case presenting with multiple purpura with ulcers and hemopurulent discharge over bilateral legs after letrozole intake for breast carcinoma. Patient was diagnosed with necrotizing CSVV due to letrozole based on history and clinico-histopathological correlation. To the best of our knowledge, this is the first report of letrozole induced necrotizing CSVV from India.https://journals.lww.com/10.4103/cdr.cdr_44_24cutaneous small vessel vasculitisletrozolevasculitis |
| spellingShingle | Liza Mohapatra Soumya Surath Panda Manoj Kumar Nayak Kallolinee Samal Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity Clinical Dermatology Review cutaneous small vessel vasculitis letrozole vasculitis |
| title | Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity |
| title_full | Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity |
| title_fullStr | Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity |
| title_full_unstemmed | Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity |
| title_short | Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity |
| title_sort | letrozole induced necrotizing cutaneous vasculitis a rare entity |
| topic | cutaneous small vessel vasculitis letrozole vasculitis |
| url | https://journals.lww.com/10.4103/cdr.cdr_44_24 |
| work_keys_str_mv | AT lizamohapatra letrozoleinducednecrotizingcutaneousvasculitisarareentity AT soumyasurathpanda letrozoleinducednecrotizingcutaneousvasculitisarareentity AT manojkumarnayak letrozoleinducednecrotizingcutaneousvasculitisarareentity AT kallolineesamal letrozoleinducednecrotizingcutaneousvasculitisarareentity |