VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation

VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation

BackgroundIndirect acute respiratory distress syndrome (iARDS) is a life-threatening inflammatory lung injury often triggered by extrapulmonary insults. Although immune checkpoints are critical regulators of inflammation, the role of V-domain Ig suppressor of T-cell activation (VISTA) in iARDS remai...

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Bibliographic Details
Main Authors: Baoji Hu, Chun-Shiang Chung, Chyna Gray, Yaping Chen, Jihong Jiang, Jianrong Guo, Alfred Ayala
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
VISTA
indirect ARDS
immune checkpoint
cytokine storm
myeloid cells
compartmentalized inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618135/full
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