Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients

Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients

Type 2 diabetes is a risk factor for colorectal cancer (CRC) development and progression. However, metformin-treated diabetic CRC patients tend to have better clinical outcomes than those managed by other means. To better characterize the molecular underpinnings of metformin’s protective effects, we...

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Bibliographic Details
Main Authors: Mary L. Fay, Chris Nicol, Christine Orr, Brooke Wilson, David Hurlbut, Harriet Feilotter, Scott Davey
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Current Oncology
Subjects:
colorectal cancer
type 2 diabetes
metformin
unfolded protein response
Online Access:https://www.mdpi.com/1718-7729/32/3/138
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