Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice

Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice

Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of the vaccine response may be limited. Antiviral treatments, such as remdesivir or molnupiravir, have demonstrated limited clinical efficacy. Nirmatrelvir, an acute respi...

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Main Authors: Mayara Mattos, Carolina Q. Sacramento, André C. Ferreira, Natalia Fintelman-Rodrigues, Filipe S. Pereira-Dutra, Caroline Souza de Freitas, João S. M. Gesto, Jairo R. Temerozo, Aline de Paula Dias Da Silva, Mariana T. G. Moreira, Rafael S. C. Silva, Gabriel P. E. Silveira, Douglas P. Pinto, Heliana M. Pereira, Laís B. Fonseca, Marcelo Alves Ferreira, Camilla Blanco, João P. B. Viola, Dumith Chequer Bou-Habib, Patrícia T. Bozza, Thiago Moreno L. Souza
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
SARS-CoV-2
anti-HCV drugs
exonuclease
error prone
K18-hACE2 mice
Online Access:https://www.mdpi.com/1999-4915/16/12/1856
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