Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study
Background To evaluate the outcomes of jaundiced neonates using 2 different total serum bilirubin (TSB) thresholds for discontinuing phototherapy. Purpose The study aims to evaluate the outcomes of jaundiced neonates by comparing 2 different TSB thresholds for discontinuing phototherapy. Methods All...
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The Korean Pediatric Society
2025-07-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://e-cep.org/upload/pdf/cep-2024-01249.pdf |
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| author | Ajay Kumar Nidhi Jain |
| author_facet | Ajay Kumar Nidhi Jain |
| author_sort | Ajay Kumar |
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| description | Background To evaluate the outcomes of jaundiced neonates using 2 different total serum bilirubin (TSB) thresholds for discontinuing phototherapy. Purpose The study aims to evaluate the outcomes of jaundiced neonates by comparing 2 different TSB thresholds for discontinuing phototherapy. Methods All consecutive jaundiced neonates in a tertiary care hospital with a gestational age of ≥35 weeks and ≥3 days postnatal age were randomly assigned to 2 groups. Results Eighty neonates were included. The mean±standard deviation TSB at the time of phototherapy discontinuation was 13.1±2.2 mg/dL in the recommended threshold group and 10.5±2.5 mg/dL in the low threshold group. After discontinuing phototherapy, 17 infants in the recommended threshold group and 21 in the low threshold group experienced an increased TSB, with 3 and 9 crossing the treatment threshold, respectively. Following the National Institute for Health and Clinical Excellence (NICE) guidelines, there was a 14.3% increase in the reinstitution of treatment, averaging 28.11 hours with no reported adverse outcomes. Conclusion Discontinuation of phototherapy in neonates led to increased TSB levels, with a reinstitution rate of 14.3%. While adherence to the NICE guidelines is important, careful posttreatment monitoring is essential. Incorporating the 2022 American Academy of Pediatrics guidelines into future research could provide a more comprehensive understanding of safe practices in this area. |
| format | Article |
| id | doaj-art-51b4322bb45a42d9ad83e3a3335fa947 |
| institution | Kabale University |
| issn | 2713-4148 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj-art-51b4322bb45a42d9ad83e3a3335fa9472025-08-20T03:33:11ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482025-07-0168753954510.3345/cep.2024.0124920125555791Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized studyAjay Kumar0Nidhi Jain1 Department of Neonatology, Maulana Azad Medical College, New Delhi, India Department of Neonatology, Maulana Azad Medical College, New Delhi, IndiaBackground To evaluate the outcomes of jaundiced neonates using 2 different total serum bilirubin (TSB) thresholds for discontinuing phototherapy. Purpose The study aims to evaluate the outcomes of jaundiced neonates by comparing 2 different TSB thresholds for discontinuing phototherapy. Methods All consecutive jaundiced neonates in a tertiary care hospital with a gestational age of ≥35 weeks and ≥3 days postnatal age were randomly assigned to 2 groups. Results Eighty neonates were included. The mean±standard deviation TSB at the time of phototherapy discontinuation was 13.1±2.2 mg/dL in the recommended threshold group and 10.5±2.5 mg/dL in the low threshold group. After discontinuing phototherapy, 17 infants in the recommended threshold group and 21 in the low threshold group experienced an increased TSB, with 3 and 9 crossing the treatment threshold, respectively. Following the National Institute for Health and Clinical Excellence (NICE) guidelines, there was a 14.3% increase in the reinstitution of treatment, averaging 28.11 hours with no reported adverse outcomes. Conclusion Discontinuation of phototherapy in neonates led to increased TSB levels, with a reinstitution rate of 14.3%. While adherence to the NICE guidelines is important, careful posttreatment monitoring is essential. Incorporating the 2022 American Academy of Pediatrics guidelines into future research could provide a more comprehensive understanding of safe practices in this area.http://e-cep.org/upload/pdf/cep-2024-01249.pdfneonatehyperbilirubinemiaphototherapy discontinuation |
| spellingShingle | Ajay Kumar Nidhi Jain Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study Clinical and Experimental Pediatrics neonate hyperbilirubinemia phototherapy discontinuation |
| title | Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study |
| title_full | Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study |
| title_fullStr | Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study |
| title_full_unstemmed | Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study |
| title_short | Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study |
| title_sort | evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates a randomized study |
| topic | neonate hyperbilirubinemia phototherapy discontinuation |
| url | http://e-cep.org/upload/pdf/cep-2024-01249.pdf |
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