Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.

Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.

The Polycomb group (PcG) and trithorax group (trxG) genes play crucial roles in development by regulating expression of homeotic and other genes controlling cell fate. Both groups catalyse modifications of chromatin, particularly histone methylation, leading to epigenetic changes that affect gene ac...

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Main Authors: Shih Chieh Liang, Ben Hartwig, Pumi Perera, Santiago Mora-García, Erica de Leau, Harry Thornton, Flavia de Lima Alves, Juri Rappsilber, Suxin Yang, Geo Velikkakam James, Korbinian Schneeberger, E Jean Finnegan, Franziska Turck, Justin Goodrich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1005660
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