The effects of age and other individual factors on radiation induced ESR signals from fingernails
Biodosimetry is crucial for assessing ionizing radiation exposure to guide medical responses. Electron spin resonance (ESR) spectroscopy using fingernails can be effectively used for both occupational and public dose assessments in radiological accidents because of their accessibility and ability to...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1531253/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527895565008896 |
|---|---|
| author | Samayeh Azariasl Samayeh Azariasl Samayeh Azariasl Hiroshi Yasuda Hiroshi Yasuda |
| author_facet | Samayeh Azariasl Samayeh Azariasl Samayeh Azariasl Hiroshi Yasuda Hiroshi Yasuda |
| author_sort | Samayeh Azariasl |
| collection | DOAJ |
| description | Biodosimetry is crucial for assessing ionizing radiation exposure to guide medical responses. Electron spin resonance (ESR) spectroscopy using fingernails can be effectively used for both occupational and public dose assessments in radiological accidents because of their accessibility and ability to retain stable radiation-induced free radicals. However, despite two decades of research, challenges remain in achieving accurate fingernail dosimetry, mainly owing to the variation in ESR signals among individuals. The purpose of this study was to explore inter-individual differences in ESR signals in fingernails to improve the accuracy and reliability of extremity dosimetry. Fingernail samples were collected from 15 participants (age: 11–64 years), irradiated with X-rays (160 kV, 6.3 mA) at 0, 5, 10, and 20 Gy, and measured using ESR spectroscopy. The effects of individual factors, such as age, sex, health condition, and lifestyle, on radiation-induced ESR signals (RIS) were investigated. Younger participants exhibited stronger RIS intensities and a more linear dose–response relationship. The RIS intensity in female samples tended to be higher than that in male samples. Interestingly, the fingernals of middle-aged donors who regularly took vitamin supplements showed significantly higher ESR signal intensities than those of similar-age donors who did not take supplements. Notable reductions in RIS intensity during storage in a freezer were observed only in older donor samples irradiated at higher doses. These findings underscores the importance of considering age and other individual factors in the calibration for fingernail dosimetry. |
| format | Article |
| id | doaj-art-51ad1706c2f540ceb894c2948ef41002 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-51ad1706c2f540ceb894c2948ef410022025-01-15T05:11:11ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011310.3389/fpubh.2025.15312531531253The effects of age and other individual factors on radiation induced ESR signals from fingernailsSamayeh Azariasl0Samayeh Azariasl1Samayeh Azariasl2Hiroshi Yasuda3Hiroshi Yasuda4Department of Radiation Biophysics, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima, JapanPhoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Hiroshima University, Hiroshima, JapanGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Radiation Biophysics, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima, JapanPhoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Hiroshima University, Hiroshima, JapanBiodosimetry is crucial for assessing ionizing radiation exposure to guide medical responses. Electron spin resonance (ESR) spectroscopy using fingernails can be effectively used for both occupational and public dose assessments in radiological accidents because of their accessibility and ability to retain stable radiation-induced free radicals. However, despite two decades of research, challenges remain in achieving accurate fingernail dosimetry, mainly owing to the variation in ESR signals among individuals. The purpose of this study was to explore inter-individual differences in ESR signals in fingernails to improve the accuracy and reliability of extremity dosimetry. Fingernail samples were collected from 15 participants (age: 11–64 years), irradiated with X-rays (160 kV, 6.3 mA) at 0, 5, 10, and 20 Gy, and measured using ESR spectroscopy. The effects of individual factors, such as age, sex, health condition, and lifestyle, on radiation-induced ESR signals (RIS) were investigated. Younger participants exhibited stronger RIS intensities and a more linear dose–response relationship. The RIS intensity in female samples tended to be higher than that in male samples. Interestingly, the fingernals of middle-aged donors who regularly took vitamin supplements showed significantly higher ESR signal intensities than those of similar-age donors who did not take supplements. Notable reductions in RIS intensity during storage in a freezer were observed only in older donor samples irradiated at higher doses. These findings underscores the importance of considering age and other individual factors in the calibration for fingernail dosimetry.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1531253/fullESR spectroscopyfingernailretrospective dosimetryradiological emergency responseinter-individual variation |
| spellingShingle | Samayeh Azariasl Samayeh Azariasl Samayeh Azariasl Hiroshi Yasuda Hiroshi Yasuda The effects of age and other individual factors on radiation induced ESR signals from fingernails Frontiers in Public Health ESR spectroscopy fingernail retrospective dosimetry radiological emergency response inter-individual variation |
| title | The effects of age and other individual factors on radiation induced ESR signals from fingernails |
| title_full | The effects of age and other individual factors on radiation induced ESR signals from fingernails |
| title_fullStr | The effects of age and other individual factors on radiation induced ESR signals from fingernails |
| title_full_unstemmed | The effects of age and other individual factors on radiation induced ESR signals from fingernails |
| title_short | The effects of age and other individual factors on radiation induced ESR signals from fingernails |
| title_sort | effects of age and other individual factors on radiation induced esr signals from fingernails |
| topic | ESR spectroscopy fingernail retrospective dosimetry radiological emergency response inter-individual variation |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1531253/full |
| work_keys_str_mv | AT samayehazariasl theeffectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT samayehazariasl theeffectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT samayehazariasl theeffectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT hiroshiyasuda theeffectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT hiroshiyasuda theeffectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT samayehazariasl effectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT samayehazariasl effectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT samayehazariasl effectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT hiroshiyasuda effectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails AT hiroshiyasuda effectsofageandotherindividualfactorsonradiationinducedesrsignalsfromfingernails |