Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features

Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features

BackgroundIn triple-negative breast cancer (TNBC), the most immunogenic breast cancer type, tumor-infiltrating lymphocytes (TILs) are an independent prognostic factor. Tertiary lymphoid structures (TLS) are an important TILs source, but they are not integrated in the current prognostic criteria.Meth...

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Bibliographic Details
Main Authors: Florence Boissière-Michot, Marie-Christine Chateau, Simon Thézenas, Virginie Lafont, Evelyne Crapez, Priyanka Sharma, Angélique Bobrie, Pascal Roger, Séverine Guiu, William Jacot
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
tertiary lymphoid structures
triple-negative breast cancer
tumor immune microenvironment
prognostic biomarker
predictive biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1507371/full
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