Transcriptome of <i>Arabidopsis thaliana</i> Plants Exposed to Human Parasites <i>Cryptosporidium parvum</i> and <i>Giardia lamblia</i>
Pathogen infection in animals and plants is recognized in a relatively similar manner by the interaction of pattern recognition receptors on the host cell surface with pathogen-associated molecular patterns on the pathogen surface. Previous work demonstrates that animal pathogenic bacteria can be re...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | International Journal of Plant Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2037-0164/16/1/13 |
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| Summary: | Pathogen infection in animals and plants is recognized in a relatively similar manner by the interaction of pattern recognition receptors on the host cell surface with pathogen-associated molecular patterns on the pathogen surface. Previous work demonstrates that animal pathogenic bacteria can be recognized by plant receptors and alter transcriptome. In this work, we have hypothesized that exposure to human parasites, <i>Cryptosporidium parvum</i> and <i>Giardia lamblia</i>, would also trigger pathogen response in plants, leading to changes in transcriptome. Detached Arabidopsis leaves were exposed for one hour to heat-inactivated <i>Cryptosporidia</i> or <i>Giardia</i>. The transcriptome profile showed large changes in gene expression with significant overlap between two parasites, including upregulated GO terms “cellular response to chitin”, “response to wounding”, “response to oomycetes”, “defense response to fungus”, “incompatible interaction”, and “activation of innate immune response”, and downregulated GO terms “positive regulation of development”, “cell surface”, “regulation of organ growth”, “wax biosynthetic process”, “leaf and shoot morphogenesis”. Uniquely downregulated GO terms in response to <i>Cryptosporidia</i> were GO terms related to chromatin remodelling, something that was not reported before. To conclude, it appears that while <i>Cryptosporidia</i> or <i>Giardia</i> are not pathogens of Arabidopsis, this plant possesses various mechanisms of recognition of pathogenic components of parasites. |
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| ISSN: | 2037-0164 |