The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction
Abstract Background Lipopolysaccharide (LPS) plays an important role in cardiovascular and renal diseases. However, the relationship between LPS and contrast-induced acute kidney injury (CI-AKI) remains unclear. This study aimed to investigate the role of LPS in patients with ST-segment elevation my...
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BMC
2025-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04959-3 |
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| author | Haiqiang Shen Qinghuan Yang Xiaofu Zhang Shan Qin Yong Li Jinqi Liu |
| author_facet | Haiqiang Shen Qinghuan Yang Xiaofu Zhang Shan Qin Yong Li Jinqi Liu |
| author_sort | Haiqiang Shen |
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| description | Abstract Background Lipopolysaccharide (LPS) plays an important role in cardiovascular and renal diseases. However, the relationship between LPS and contrast-induced acute kidney injury (CI-AKI) remains unclear. This study aimed to investigate the role of LPS in patients with ST-segment elevation myocardial infarction (STEMI) and its relationship with CI-AKI following percutaneous coronary intervention (PCI). Methods This single-centre retrospective observational study included 710 patients diagnosed with STEMI. CI-AKI was defined as an increase in SCr of at least 50% or 0.3 mg/dL within 48–72 h after contrast exposure. Regression analysis was used to identify potential risk factors. Restricted cubic splines (RCSs) were used to explore the dose‒response relationship between LPS levels and CI-AKI. The models were evaluated using receiver operating characteristic (ROC) curves, the net reclassification index (NRI), and the integrated discrimination improvement (IDI) index. Results The incidence of CI-AKI during hospitalization was 12.5%. After adjusting for potential confounding factors, the results revealed that LPS (OR = 0.650, 95% CI: 0.466–0.906) was an independent risk factor that affected the occurrence of CI-AKI. The RCS results revealed a linear dose‒response relationship between LPS and CI-AKI. After integration of LPS, the model demonstrated a significantly improved ability to predict CI-AKI (IDI 0.095, P < 0.001; NRI 0.720, P < 0.001). Conclusion Elevated LPS is an independent risk factor for the development of CI-AKI after PCI in patients with STEMI. The integration of LPS detection significantly improved the risk model for CI-AKI. |
| format | Article |
| id | doaj-art-519d609ea1e743cf9db22d8d283d1e37 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-519d609ea1e743cf9db22d8d283d1e372025-08-20T03:42:23ZengBMCBMC Cardiovascular Disorders1471-22612025-07-012511910.1186/s12872-025-04959-3The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarctionHaiqiang Shen0Qinghuan Yang1Xiaofu Zhang2Shan Qin3Yong Li4Jinqi Liu5Department of Gastroenterology, the First People’s Hospital of Yuhang DistrictDepartment of Cardiology, the First People’s Hospital of Yuhang DistrictDepartment of Cardiology, the First People’s Hospital of Yuhang DistrictDepartment of Cardiology, the First People’s Hospital of Yuhang DistrictDepartment of Cardiology, the First People’s Hospital of Yuhang DistrictDepartment of Cardiology, Huai’an Second People’s HospitalAbstract Background Lipopolysaccharide (LPS) plays an important role in cardiovascular and renal diseases. However, the relationship between LPS and contrast-induced acute kidney injury (CI-AKI) remains unclear. This study aimed to investigate the role of LPS in patients with ST-segment elevation myocardial infarction (STEMI) and its relationship with CI-AKI following percutaneous coronary intervention (PCI). Methods This single-centre retrospective observational study included 710 patients diagnosed with STEMI. CI-AKI was defined as an increase in SCr of at least 50% or 0.3 mg/dL within 48–72 h after contrast exposure. Regression analysis was used to identify potential risk factors. Restricted cubic splines (RCSs) were used to explore the dose‒response relationship between LPS levels and CI-AKI. The models were evaluated using receiver operating characteristic (ROC) curves, the net reclassification index (NRI), and the integrated discrimination improvement (IDI) index. Results The incidence of CI-AKI during hospitalization was 12.5%. After adjusting for potential confounding factors, the results revealed that LPS (OR = 0.650, 95% CI: 0.466–0.906) was an independent risk factor that affected the occurrence of CI-AKI. The RCS results revealed a linear dose‒response relationship between LPS and CI-AKI. After integration of LPS, the model demonstrated a significantly improved ability to predict CI-AKI (IDI 0.095, P < 0.001; NRI 0.720, P < 0.001). Conclusion Elevated LPS is an independent risk factor for the development of CI-AKI after PCI in patients with STEMI. The integration of LPS detection significantly improved the risk model for CI-AKI.https://doi.org/10.1186/s12872-025-04959-3Contrast-induced acute kidney injuryLipopolysaccharideSTEMIAcute kidney injuryPercutaneous coronary intervention |
| spellingShingle | Haiqiang Shen Qinghuan Yang Xiaofu Zhang Shan Qin Yong Li Jinqi Liu The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction BMC Cardiovascular Disorders Contrast-induced acute kidney injury Lipopolysaccharide STEMI Acute kidney injury Percutaneous coronary intervention |
| title | The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction |
| title_full | The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction |
| title_fullStr | The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction |
| title_full_unstemmed | The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction |
| title_short | The plasma lipopolysaccharide level is associated with contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction |
| title_sort | plasma lipopolysaccharide level is associated with contrast induced acute kidney injury in patients with st segment elevation myocardial infarction |
| topic | Contrast-induced acute kidney injury Lipopolysaccharide STEMI Acute kidney injury Percutaneous coronary intervention |
| url | https://doi.org/10.1186/s12872-025-04959-3 |
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