SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue

SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue

Postmortem human brain tissue is a critical resource for studying neurodegenerative disease, providing critical insights into cellular morphology, pathology, and network connectivity. To improve standard microscopy and enable high-resolution, three-dimensional (3D) images of tissues at the subcellul...

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Bibliographic Details
Main Authors: Grace A. Rosen, Daniel Kirsch, Raymond Nicks, Hunter Kelley, Rebecca Mathias, Kerry A. Cormier, Caroline A. Kubilus, Bryan Dec, Thor D. Stein, Victor E. Alvarez, Michael L. Alosco, Ann C. McKee, Bertrand R. Huber
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Neuroscience
Subjects:
optical clearing
antigen retrieval
volumetric imaging
3D confocal imaging
3D confocal laser scanning microscopy
human brain banking
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1474617/full
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