Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway

Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway

Diabetic cardiomyopathy (DCM) is a specific type of cardiac dysfunction in diabetic patients, currently has no effective therapies. The TLR4 signaling pathway, activated through MyD88 and NF-κB, plays a critical role in DCM by triggering the release of pro-inflammatory cytokines and promoting pyropt...

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Bibliographic Details
Main Authors: Xuan Zhou, Shaoliang Xing, Lina Zhang, Jungu Lu, Deming Li, Yating Wang, Yuhang Ma, Weiqin Chang, Manman Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
diabetic cardiomyopathy
type 2 diabetes mellitus
amniotic mesenchymal stem cells
fibrosis
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1631973/full
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