Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model

Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model

Abstract Many neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha+ (PDGFRα+) oligodendroglial lineage cells resp...

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Bibliographic Details
Main Authors: Noriko Okuno, Seiji Yamamoto, Takeru Hamashima, Tung Son Dang, Naruho Okita, Miwa Fujikawa, Tomomi Kunisawa, Nobuyuki Takakura, Toshihiko Fujimori, Hisashi Mori, Christer Betsholtz, Katsuyoshi Takata, Masakiyo Sasahara
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Angiogenesis
Border-associated macrophage
Fibrosis
Myelination failure
PDGFRα
Perivascular fibroblast
Online Access:https://doi.org/10.1186/s40478-025-02063-3
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