Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis
Abstract. Background. Acute severe organophosphorus pesticide poisoning is a common severe emergency in developing countries. Our meta-analysis aimed to clarify the efficacy of hemoperfusion combined with hemodialysis on acute severe organophosphorus pesticide poisoning. Methods. Several databases w...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2023-12-01
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| Series: | Emergency and Critical Care Medicine |
| Online Access: | http://journals.lww.com/10.1097/EC9.0000000000000070 |
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| author | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Yi Gou Yi Li |
| author_facet | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Yi Gou Yi Li |
| author_sort | Siyao Zeng |
| collection | DOAJ |
| description | Abstract. Background. Acute severe organophosphorus pesticide poisoning is a common severe emergency in developing countries. Our meta-analysis aimed to clarify the efficacy of hemoperfusion combined with hemodialysis on acute severe organophosphorus pesticide poisoning.
Methods. Several databases were searched. After formulating relevant inclusion and exclusion criteria, qualified studies were included, and the data were extracted. The outcome indicators were the success rate of rescue, the time of hospitalization, the incidence of complications, the time for the cholinesterase level to return to normal, the coma time, and the atropine dosage. The results were analyzed using risk ratios, weighted mean difference, standard mean difference, and 95% confidence interval. The Cochrane Collaboration tool was used to assess the risk of bias in all the included studies. In terms of statistical methods, we used RevMan software (version 5.3; The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and Stata (versions 14 and 16; StataCorp, College Station, TX, USA) for the data analysis.
Results. We included 92 randomized controlled trials with 6899 participants. Compared with the conventional emergency treatment group (CET group), the hemoperfusion group (HP + CET group), and the hemodialysis group (HD + CET group), the use of hemoperfusion combined with hemodialysis based on CET (HP + HD + CET group) significantly increased the success rate of rescue and reduced hospitalization time, the incidence of complications, time for cholinesterase level to return to normal, coma time, and atropine dosage.
Conclusion. Hemoperfusion combined with hemodialysis is effective in the treatment of acute severe organophosphorus pesticide poisoning. In the future, more scientifically designed, large-scale, high-quality, multicenter randomized controlled trials are needed to validate this study further. |
| format | Article |
| id | doaj-art-518d30e05a164d0da4b77f85f91b3b17 |
| institution | OA Journals |
| issn | 2097-0617 2693-860X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Emergency and Critical Care Medicine |
| spelling | doaj-art-518d30e05a164d0da4b77f85f91b3b172025-08-20T02:26:10ZengWolters Kluwer Health/LWWEmergency and Critical Care Medicine2097-06172693-860X2023-12-013417719310.1097/EC9.0000000000000070202312000-00007Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysisSiyao Zeng0Lei Ma1Lishan Yang2Xiaodong Hu3Cheng Wang4Yi Gou5Yi Li6a School of Clinical Medicine of Ningxia Medical University, Yinchuan, Ningxia, Chinab Department of Emergency Medicine, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, Ningxia, China.b Department of Emergency Medicine, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, Ningxia, China.b Department of Emergency Medicine, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, Ningxia, China.a School of Clinical Medicine of Ningxia Medical University, Yinchuan, Ningxia, Chinaa School of Clinical Medicine of Ningxia Medical University, Yinchuan, Ningxia, Chinaa School of Clinical Medicine of Ningxia Medical University, Yinchuan, Ningxia, ChinaAbstract. Background. Acute severe organophosphorus pesticide poisoning is a common severe emergency in developing countries. Our meta-analysis aimed to clarify the efficacy of hemoperfusion combined with hemodialysis on acute severe organophosphorus pesticide poisoning. Methods. Several databases were searched. After formulating relevant inclusion and exclusion criteria, qualified studies were included, and the data were extracted. The outcome indicators were the success rate of rescue, the time of hospitalization, the incidence of complications, the time for the cholinesterase level to return to normal, the coma time, and the atropine dosage. The results were analyzed using risk ratios, weighted mean difference, standard mean difference, and 95% confidence interval. The Cochrane Collaboration tool was used to assess the risk of bias in all the included studies. In terms of statistical methods, we used RevMan software (version 5.3; The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and Stata (versions 14 and 16; StataCorp, College Station, TX, USA) for the data analysis. Results. We included 92 randomized controlled trials with 6899 participants. Compared with the conventional emergency treatment group (CET group), the hemoperfusion group (HP + CET group), and the hemodialysis group (HD + CET group), the use of hemoperfusion combined with hemodialysis based on CET (HP + HD + CET group) significantly increased the success rate of rescue and reduced hospitalization time, the incidence of complications, time for cholinesterase level to return to normal, coma time, and atropine dosage. Conclusion. Hemoperfusion combined with hemodialysis is effective in the treatment of acute severe organophosphorus pesticide poisoning. In the future, more scientifically designed, large-scale, high-quality, multicenter randomized controlled trials are needed to validate this study further.http://journals.lww.com/10.1097/EC9.0000000000000070 |
| spellingShingle | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Yi Gou Yi Li Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis Emergency and Critical Care Medicine |
| title | Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis |
| title_full | Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis |
| title_fullStr | Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis |
| title_full_unstemmed | Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis |
| title_short | Role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning: a meta-analysis |
| title_sort | role of hemoperfusion combined with hemodialysis in acute severe organophosphorus pesticide poisoning a meta analysis |
| url | http://journals.lww.com/10.1097/EC9.0000000000000070 |
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