Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019
Background This study assessed changes in Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility among hospitalized children with pneumonia in Shenzhen, China, from 2009 to 2019, under low pneumococcal conjugate vaccine (PCV) coverage.Research Design and Methods We analyz...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14760584.2025.2531898 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849709307273150464 |
|---|---|
| author | Feiling Wang Xiaojing Zeng Qianqian Du Yingqi Deng Jing Peng Rui Dong Wenyan Hu Hongbo Xie Wei Shi Haitao Chen Ping Jin Kaihu Yao Lijuan Wu |
| author_facet | Feiling Wang Xiaojing Zeng Qianqian Du Yingqi Deng Jing Peng Rui Dong Wenyan Hu Hongbo Xie Wei Shi Haitao Chen Ping Jin Kaihu Yao Lijuan Wu |
| author_sort | Feiling Wang |
| collection | DOAJ |
| description | Background This study assessed changes in Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility among hospitalized children with pneumonia in Shenzhen, China, from 2009 to 2019, under low pneumococcal conjugate vaccine (PCV) coverage.Research Design and Methods We analyzed 1,361 isolates (62 invasive, 1,299 noninvasive). Serotypes were identified by latex agglutination and Quellung reaction. Antimicrobial susceptibility was determined using E-test, and vaccination data were obtained from the local CDC.Results PCV13 serotype coverage remained high among invasive isolates (96.8%) and represented a substantial proportion of all isolates. A marked decline in serotype 19F (from 59.2% to 14.4%) and increased serotype diversity (from 14 to 26 types) were observed. Non-susceptible rates to four beta-lactam antibiotics decreased from 16.0% to 2.4%, largely due to the decline of serotype 19F. PCV vaccination rates rose to 31.1% by 2019. Non-vaccine serotypes increased over time, with some (e.g. 15B/C) showing elevated beta-lactam MICs.Conclusions Despite low vaccination rate, PCV13 serotypes remained predominant among isolates. The decline of serotype 19F and reduced beta-lactam nonsusceptibility suggest vaccine impact. Rising serotype diversity and the emergence of nonsusceptible non-vaccine types highlight the need for continued surveillance. |
| format | Article |
| id | doaj-art-51873fbf6e0645579dcd01695dbde2b4 |
| institution | DOAJ |
| issn | 1476-0584 1744-8395 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj-art-51873fbf6e0645579dcd01695dbde2b42025-08-20T03:15:20ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952025-12-0124159060010.1080/14760584.2025.2531898Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019Feiling Wang0Xiaojing Zeng1Qianqian Du2Yingqi Deng3Jing Peng4Rui Dong5Wenyan Hu6Hongbo Xie7Wei Shi8Haitao Chen9Ping Jin10Kaihu Yao11Lijuan Wu12Clinical Laboratory, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaClinical Laboratory, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics, Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaClinical Laboratory, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaImmunization Division, Baoan Center for Disease Control and Prevention of Shenzhen, Shenzhen, ChinaClinical Laboratory, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaDepartment of Pediatrics, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics, Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaDepartment of Pediatrics, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics, Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaClinical Laboratory, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaBackground This study assessed changes in Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility among hospitalized children with pneumonia in Shenzhen, China, from 2009 to 2019, under low pneumococcal conjugate vaccine (PCV) coverage.Research Design and Methods We analyzed 1,361 isolates (62 invasive, 1,299 noninvasive). Serotypes were identified by latex agglutination and Quellung reaction. Antimicrobial susceptibility was determined using E-test, and vaccination data were obtained from the local CDC.Results PCV13 serotype coverage remained high among invasive isolates (96.8%) and represented a substantial proportion of all isolates. A marked decline in serotype 19F (from 59.2% to 14.4%) and increased serotype diversity (from 14 to 26 types) were observed. Non-susceptible rates to four beta-lactam antibiotics decreased from 16.0% to 2.4%, largely due to the decline of serotype 19F. PCV vaccination rates rose to 31.1% by 2019. Non-vaccine serotypes increased over time, with some (e.g. 15B/C) showing elevated beta-lactam MICs.Conclusions Despite low vaccination rate, PCV13 serotypes remained predominant among isolates. The decline of serotype 19F and reduced beta-lactam nonsusceptibility suggest vaccine impact. Rising serotype diversity and the emergence of nonsusceptible non-vaccine types highlight the need for continued surveillance.https://www.tandfonline.com/doi/10.1080/14760584.2025.2531898Streptococcus pneumoniaeserotype distributionantibiotic nonsusceptibilitypneumococcal conjugate vaccinevaccination ratespneumonia |
| spellingShingle | Feiling Wang Xiaojing Zeng Qianqian Du Yingqi Deng Jing Peng Rui Dong Wenyan Hu Hongbo Xie Wei Shi Haitao Chen Ping Jin Kaihu Yao Lijuan Wu Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 Expert Review of Vaccines Streptococcus pneumoniae serotype distribution antibiotic nonsusceptibility pneumococcal conjugate vaccine vaccination rates pneumonia |
| title | Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 |
| title_full | Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 |
| title_fullStr | Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 |
| title_full_unstemmed | Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 |
| title_short | Changes in serotype distribution and antimicrobial nonsusceptibility of Streptococcus pneumoniae among hospitalized children: Shenzhen, China, 2009–2019 |
| title_sort | changes in serotype distribution and antimicrobial nonsusceptibility of streptococcus pneumoniae among hospitalized children shenzhen china 2009 2019 |
| topic | Streptococcus pneumoniae serotype distribution antibiotic nonsusceptibility pneumococcal conjugate vaccine vaccination rates pneumonia |
| url | https://www.tandfonline.com/doi/10.1080/14760584.2025.2531898 |
| work_keys_str_mv | AT feilingwang changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT xiaojingzeng changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT qianqiandu changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT yingqideng changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT jingpeng changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT ruidong changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT wenyanhu changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT hongboxie changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT weishi changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT haitaochen changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT pingjin changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT kaihuyao changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 AT lijuanwu changesinserotypedistributionandantimicrobialnonsusceptibilityofstreptococcuspneumoniaeamonghospitalizedchildrenshenzhenchina20092019 |