Implication of protein post translational modifications in gastric cancer
Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. Eme...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1523958/full |
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| author | Houji Song Mingze Zhang Chengwang Guo Xi Guo Yuqi Ma Yuntao Ma Yuntao Ma |
| author_facet | Houji Song Mingze Zhang Chengwang Guo Xi Guo Yuqi Ma Yuntao Ma Yuntao Ma |
| author_sort | Houji Song |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. Emerging research has highlighted lactylation and glycosylation. The diverse realm of PTM and PTM crosstalk is linked to many critical signaling events involved in neoplastic transformation, carcinogenesis and metastasis. This review provides a comprehensive overview of the impact of PTM on the occurrence and progression of GC. Specifically, aberrant PTM have been shown to alter the proliferation, migration, and invasion capabilities of GC cells. Moreover, PTM are closely associated with resistance to chemotherapeutic agents in GC. Notably, this review also discusses the phenomenon of PTM crosstalk, highlighting the interactions among PTM and their roles in regulating signaling pathways and protein functions. Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions. |
| format | Article |
| id | doaj-art-51859abe1dcd4c00a82c3d3000029fb5 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-51859abe1dcd4c00a82c3d3000029fb52025-02-04T09:23:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.15239581523958Implication of protein post translational modifications in gastric cancerHouji Song0Mingze Zhang1Chengwang Guo2Xi Guo3Yuqi Ma4Yuntao Ma5Yuntao Ma6The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaDepartment of General Surgery, Gansu Provincial Hospital, Lanzhou, ChinaGastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. Emerging research has highlighted lactylation and glycosylation. The diverse realm of PTM and PTM crosstalk is linked to many critical signaling events involved in neoplastic transformation, carcinogenesis and metastasis. This review provides a comprehensive overview of the impact of PTM on the occurrence and progression of GC. Specifically, aberrant PTM have been shown to alter the proliferation, migration, and invasion capabilities of GC cells. Moreover, PTM are closely associated with resistance to chemotherapeutic agents in GC. Notably, this review also discusses the phenomenon of PTM crosstalk, highlighting the interactions among PTM and their roles in regulating signaling pathways and protein functions. Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions.https://www.frontiersin.org/articles/10.3389/fcell.2025.1523958/fullgastric cancerubiquitinationphosphorylationacetylationglycosylationmethylation |
| spellingShingle | Houji Song Mingze Zhang Chengwang Guo Xi Guo Yuqi Ma Yuntao Ma Yuntao Ma Implication of protein post translational modifications in gastric cancer Frontiers in Cell and Developmental Biology gastric cancer ubiquitination phosphorylation acetylation glycosylation methylation |
| title | Implication of protein post translational modifications in gastric cancer |
| title_full | Implication of protein post translational modifications in gastric cancer |
| title_fullStr | Implication of protein post translational modifications in gastric cancer |
| title_full_unstemmed | Implication of protein post translational modifications in gastric cancer |
| title_short | Implication of protein post translational modifications in gastric cancer |
| title_sort | implication of protein post translational modifications in gastric cancer |
| topic | gastric cancer ubiquitination phosphorylation acetylation glycosylation methylation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1523958/full |
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