PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing

PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing

ABSTRACT Non-typhoidal Salmonella serovars, such as Salmonella enterica serovar Typhimurium (STm), are a leading cause of inflammatory diarrhea in otherwise healthy individuals. Among children, the elderly, and immunocompromised individuals, STm can spread to systemic sites and cause potentially let...

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Main Authors: Michael H. Lee, Araceli Perez-Lopez, Leigh A. Knodler, Grace Nguyen, Gregory T. Walker, Judith Behnsen, Steven Silva, Jean Celli, Melissa A. Tamin, Michael H. Liang, Karine Melchior, Felix A. Argueta, Sean-Paul Nuccio, Manuela Raffatellu
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
Salmonella
complement
neutrophils
macrophages
proteases
bacteremia
Online Access:https://journals.asm.org/doi/10.1128/mbio.03802-24
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