Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus
IntroductionAbdominal aortic aneurysm (AAA) is a life-threatening disease marked by localized dilatations of the infrarenal aortic wall. While clinical guidelines often use the aneurysm diameter as an indicator for surgical intervention, this metric alone may not reliably predict rupture risks, unde...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1519608/full |
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| author | Xinhai Yue Jiayi Huang Ju Liu |
| author_facet | Xinhai Yue Jiayi Huang Ju Liu |
| author_sort | Xinhai Yue |
| collection | DOAJ |
| description | IntroductionAbdominal aortic aneurysm (AAA) is a life-threatening disease marked by localized dilatations of the infrarenal aortic wall. While clinical guidelines often use the aneurysm diameter as an indicator for surgical intervention, this metric alone may not reliably predict rupture risks, underscoring the need for detailed biomechanical analyses to improve risk assessments.MethodsWe investigate the effects of the multi-layered tissue architecture and the intraluminal thrombus (ILT) on the wall stress distribution of AAA. Using fluid-structure interaction, we analyze the biomechanical responses of fusiform and saccular AAAs under three conditions: without ILT, with ILT but no tissue degradation, and with both ILT and tissue degradation.ResultsThe findings show that the media is the primary load-bearing layer, and the multi-layered model yields a more accurate stress profile than the single-layered tissue model. The ILT substantially reduces overall stress levels in the covered tissue, although its impact on the location of peak stress varies across different scenarios. Media degradation increases the stress in the intima and adventitia, but the cushioning effect of ILT largely mitigates this impact.DiscussionThe results underscore the importance of incorporating the multi-layered tissue architecture and ILT in patient-specific analyses of AAA. These factors may improve the predictive capabilities of biomechanical assessments for rupture risk. |
| format | Article |
| id | doaj-art-51813254118d4d5198d2b7e151773e90 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-51813254118d4d5198d2b7e151773e902025-02-11T06:59:55ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15196081519608Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombusXinhai YueJiayi HuangJu LiuIntroductionAbdominal aortic aneurysm (AAA) is a life-threatening disease marked by localized dilatations of the infrarenal aortic wall. While clinical guidelines often use the aneurysm diameter as an indicator for surgical intervention, this metric alone may not reliably predict rupture risks, underscoring the need for detailed biomechanical analyses to improve risk assessments.MethodsWe investigate the effects of the multi-layered tissue architecture and the intraluminal thrombus (ILT) on the wall stress distribution of AAA. Using fluid-structure interaction, we analyze the biomechanical responses of fusiform and saccular AAAs under three conditions: without ILT, with ILT but no tissue degradation, and with both ILT and tissue degradation.ResultsThe findings show that the media is the primary load-bearing layer, and the multi-layered model yields a more accurate stress profile than the single-layered tissue model. The ILT substantially reduces overall stress levels in the covered tissue, although its impact on the location of peak stress varies across different scenarios. Media degradation increases the stress in the intima and adventitia, but the cushioning effect of ILT largely mitigates this impact.DiscussionThe results underscore the importance of incorporating the multi-layered tissue architecture and ILT in patient-specific analyses of AAA. These factors may improve the predictive capabilities of biomechanical assessments for rupture risk.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1519608/fullfluid-structure interactionabdominal aortic aneurysmintraluminal thrombusmulti-layered anisotropic tissue modelpatient-specific modeling |
| spellingShingle | Xinhai Yue Jiayi Huang Ju Liu Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus Frontiers in Bioengineering and Biotechnology fluid-structure interaction abdominal aortic aneurysm intraluminal thrombus multi-layered anisotropic tissue model patient-specific modeling |
| title | Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus |
| title_full | Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus |
| title_fullStr | Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus |
| title_full_unstemmed | Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus |
| title_short | Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus |
| title_sort | fluid structure interaction analysis for abdominal aortic aneurysms the role of multi layered tissue architecture and intraluminal thrombus |
| topic | fluid-structure interaction abdominal aortic aneurysm intraluminal thrombus multi-layered anisotropic tissue model patient-specific modeling |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1519608/full |
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