The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats
Influence of cytoskeleton modulation by Colchicine and Cytochalasine B on contractile reactions of smooth muscle segments of rat's aorta caused by physiologically active substances, the membrane's depolarization and cells' striction was investigated by mechanographical method. Microtu...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2007-03-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3224 |
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| author | S. V. Gousakova |
| author_facet | S. V. Gousakova |
| author_sort | S. V. Gousakova |
| collection | DOAJ |
| description | Influence of cytoskeleton modulation by Colchicine and Cytochalasine B on contractile reactions of smooth muscle segments of rat's aorta caused by physiologically active substances, the membrane's depolarization and cells' striction was investigated by mechanographical method. Microtubules and actinic elements of the cytoskeleton were established to participate in the development of hyper-potassic and phenylephrine -induced contractions as well as in the smooth muscle relaxation induced by cAMP. Cytochalasine B suppresses both kinds of aortic smooth muscle contractions more effectively than Colchicine. Contractile reactions at isoosmotic striction are suppressed only by Cytochalasine. Efficacy of cAMP signal system operating depends on actinic cyto-skeleton integrity. |
| format | Article |
| id | doaj-art-517b71d628f942e387ee7c06025f6338 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2007-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-517b71d628f942e387ee7c06025f63382025-08-20T03:37:17ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842007-03-0161788210.20538/1682-0363-2007-1-78-821880The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of ratsS. V. Gousakova0Сибирский государственный медицинский университетInfluence of cytoskeleton modulation by Colchicine and Cytochalasine B on contractile reactions of smooth muscle segments of rat's aorta caused by physiologically active substances, the membrane's depolarization and cells' striction was investigated by mechanographical method. Microtubules and actinic elements of the cytoskeleton were established to participate in the development of hyper-potassic and phenylephrine -induced contractions as well as in the smooth muscle relaxation induced by cAMP. Cytochalasine B suppresses both kinds of aortic smooth muscle contractions more effectively than Colchicine. Contractile reactions at isoosmotic striction are suppressed only by Cytochalasine. Efficacy of cAMP signal system operating depends on actinic cyto-skeleton integrity.https://bulletin.ssmu.ru/jour/article/view/3224smooth muscle cellscytoskeletoncamp signal system |
| spellingShingle | S. V. Gousakova The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats Бюллетень сибирской медицины smooth muscle cells cytoskeleton camp signal system |
| title | The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| title_full | The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| title_fullStr | The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| title_full_unstemmed | The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| title_short | The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| title_sort | role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats |
| topic | smooth muscle cells cytoskeleton camp signal system |
| url | https://bulletin.ssmu.ru/jour/article/view/3224 |
| work_keys_str_mv | AT svgousakova theroleofcytoskeletonintheregulationofcontractileactivityinsmoothmusclecellsfromaortaofrats AT svgousakova roleofcytoskeletonintheregulationofcontractileactivityinsmoothmusclecellsfromaortaofrats |