Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated disease of the brain that follows viral infection or vaccination, or even appears spontaneously. The objective of the study was to evaluate the clinical, neuroimaging and laboratory profiles of children with ADEM. Seventeen chi...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2014-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1411 |
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| author | Gurdeep S Dhooria Harmesh S Bains Deepak Bhat Shalini Wats |
| author_facet | Gurdeep S Dhooria Harmesh S Bains Deepak Bhat Shalini Wats |
| author_sort | Gurdeep S Dhooria |
| collection | DOAJ |
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Acute disseminated encephalomyelitis (ADEM) is an immune-mediated disease of the brain that follows viral infection or vaccination, or even appears spontaneously. The objective of the study was to evaluate the clinical, neuroimaging and laboratory profiles of children with ADEM. Seventeen children admitted to the Pediatric Department of Dayanand Medical College and Hospital, Ludhiana, whose cases were consistent with the diagnosis of ADEM, were included. Their clinical and neuroimaging profiles and outcomes were studied. The most common presenting features were fever (71%), altered sensorium (59%) and headache and convulsions (41%). Brain MRI identified lesions in subcortical white matter (75%) and periventricular white matter (38%). Most patients were treated with corticosteroids. A favorable outcome was seen in 88% of patients. Although 59% of patients had neurologic sequelae at discharge, only one patient had a major neurological deficit at follow-up. Prognosis for survival and outcome was good in the majority of patients. Neurological sequelae at discharge do not predict poor outcome.
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| format | Article |
| id | doaj-art-517a50d27eaa4fc9b6f15119c13aa9cb |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-517a50d27eaa4fc9b6f15119c13aa9cb2025-08-20T02:55:23ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212014-10-01565Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in IndiaGurdeep S Dhooria0Harmesh S BainsDeepak BhatShalini WatsDepartment of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, India. gurdeep2005_123@sify.com. Acute disseminated encephalomyelitis (ADEM) is an immune-mediated disease of the brain that follows viral infection or vaccination, or even appears spontaneously. The objective of the study was to evaluate the clinical, neuroimaging and laboratory profiles of children with ADEM. Seventeen children admitted to the Pediatric Department of Dayanand Medical College and Hospital, Ludhiana, whose cases were consistent with the diagnosis of ADEM, were included. Their clinical and neuroimaging profiles and outcomes were studied. The most common presenting features were fever (71%), altered sensorium (59%) and headache and convulsions (41%). Brain MRI identified lesions in subcortical white matter (75%) and periventricular white matter (38%). Most patients were treated with corticosteroids. A favorable outcome was seen in 88% of patients. Although 59% of patients had neurologic sequelae at discharge, only one patient had a major neurological deficit at follow-up. Prognosis for survival and outcome was good in the majority of patients. Neurological sequelae at discharge do not predict poor outcome. https://turkjpediatr.org/article/view/1411 |
| spellingShingle | Gurdeep S Dhooria Harmesh S Bains Deepak Bhat Shalini Wats Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India The Turkish Journal of Pediatrics |
| title | Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India |
| title_full | Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India |
| title_fullStr | Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India |
| title_full_unstemmed | Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India |
| title_short | Outcome of children with acute disseminated encephalomyelitis in a tertiary care center in India |
| title_sort | outcome of children with acute disseminated encephalomyelitis in a tertiary care center in india |
| url | https://turkjpediatr.org/article/view/1411 |
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