Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy
Bispecific antibodies, such as talquetamab and teclistamab, offer promising treatment options for refractory multiple myeloma but are associated with significant immunosuppression and susceptibility to atypical infections. We report a case of recurrent Campylobacter jejuni meningitis in a 44-year-ol...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2025.0121 |
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| _version_ | 1850232519258013696 |
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| author | Gal Sharvit Avshalom Leibowitz Ana Belkin |
| author_facet | Gal Sharvit Avshalom Leibowitz Ana Belkin |
| author_sort | Gal Sharvit |
| collection | DOAJ |
| description | Bispecific antibodies, such as talquetamab and teclistamab, offer promising treatment options for refractory multiple myeloma but are associated with significant immunosuppression and susceptibility to atypical infections. We report a case of recurrent Campylobacter jejuni meningitis in a 44-year-old man undergoing talquetamab and teclistamab therapy, highlighting the role of hypogammaglobulinemia in disease recurrence. Diagnosis was confirmed using molecular tools, emphasizing their value in detecting pathogens with low bacterial loads. This case underscores the need for vigilance, advanced diagnostics, and tailored prophylaxis to mitigate infection risks in immunocompromised patients receiving novel therapies. |
| format | Article |
| id | doaj-art-5174d855f3634a88b235acbd7bd1459f |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-5174d855f3634a88b235acbd7bd1459f2025-08-20T02:03:08ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-06-014610.7326/aimcc.2025.0121Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody TherapyGal Sharvit0Avshalom Leibowitz1Ana Belkin21Internal Medicine D, Sheba Medical Center, Ramat-Gan, Israel1Internal Medicine D, Sheba Medical Center, Ramat-Gan, Israel1Internal Medicine D, Sheba Medical Center, Ramat-Gan, IsraelBispecific antibodies, such as talquetamab and teclistamab, offer promising treatment options for refractory multiple myeloma but are associated with significant immunosuppression and susceptibility to atypical infections. We report a case of recurrent Campylobacter jejuni meningitis in a 44-year-old man undergoing talquetamab and teclistamab therapy, highlighting the role of hypogammaglobulinemia in disease recurrence. Diagnosis was confirmed using molecular tools, emphasizing their value in detecting pathogens with low bacterial loads. This case underscores the need for vigilance, advanced diagnostics, and tailored prophylaxis to mitigate infection risks in immunocompromised patients receiving novel therapies.https://www.acpjournals.org/doi/10.7326/aimcc.2025.0121 |
| spellingShingle | Gal Sharvit Avshalom Leibowitz Ana Belkin Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy Annals of Internal Medicine: Clinical Cases |
| title | Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy |
| title_full | Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy |
| title_fullStr | Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy |
| title_full_unstemmed | Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy |
| title_short | Meningitis Caused by Campylobacter jejuni in a Patient With Immunodeficiency Due to Bispecific Antibody Therapy |
| title_sort | meningitis caused by campylobacter jejuni in a patient with immunodeficiency due to bispecific antibody therapy |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2025.0121 |
| work_keys_str_mv | AT galsharvit meningitiscausedbycampylobacterjejuniinapatientwithimmunodeficiencyduetobispecificantibodytherapy AT avshalomleibowitz meningitiscausedbycampylobacterjejuniinapatientwithimmunodeficiencyduetobispecificantibodytherapy AT anabelkin meningitiscausedbycampylobacterjejuniinapatientwithimmunodeficiencyduetobispecificantibodytherapy |