Beyond CCR7: dendritic cell migration in type 2 inflammation
Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues to draining lymph nodes (dLNs) is essential f...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558228/full |
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| author | Audrey Meloun Audrey Meloun Beatriz León |
| author_facet | Audrey Meloun Audrey Meloun Beatriz León |
| author_sort | Audrey Meloun |
| collection | DOAJ |
| description | Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues to draining lymph nodes (dLNs) is essential for their function in immune surveillance. This migration allows cDCs to convey the conditions of peripheral tissues to antigen-specific T cells in the dLNs, facilitating effective immune responses. Migration is primarily mediated by chemokine receptor CCR7, which is upregulated in response to homeostatic and inflammatory cues, guiding cDCs to dLNs. However, during type 2 immune responses, such as those triggered by parasites or allergens, a paradox arises—cDCs exhibit robust migration to dLNs despite low CCR7 expression. This review discusses how type 2 inflammation relies on additional signaling pathways, including those induced by membrane-derived bioactive lipid mediators like eicosanoids, sphingolipids, and oxysterols, which cooperate with CCR7 to enhance cDC migration and T helper 2 (Th2) differentiation. We explore the potential regulatory mechanisms of cDC migration in type 2 immunity, offering insights into the differential control of cDC trafficking in diverse immune contexts and its impact on immune responses. |
| format | Article |
| id | doaj-art-5172d5c9b9c84811a6ffb3e82ebd7cfe |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5172d5c9b9c84811a6ffb3e82ebd7cfe2025-08-20T02:04:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15582281558228Beyond CCR7: dendritic cell migration in type 2 inflammationAudrey Meloun0Audrey Meloun1Beatriz León2Innate Cells and Th2 Immunity Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United StatesInnate Cells and Th2 Immunity Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesConventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues to draining lymph nodes (dLNs) is essential for their function in immune surveillance. This migration allows cDCs to convey the conditions of peripheral tissues to antigen-specific T cells in the dLNs, facilitating effective immune responses. Migration is primarily mediated by chemokine receptor CCR7, which is upregulated in response to homeostatic and inflammatory cues, guiding cDCs to dLNs. However, during type 2 immune responses, such as those triggered by parasites or allergens, a paradox arises—cDCs exhibit robust migration to dLNs despite low CCR7 expression. This review discusses how type 2 inflammation relies on additional signaling pathways, including those induced by membrane-derived bioactive lipid mediators like eicosanoids, sphingolipids, and oxysterols, which cooperate with CCR7 to enhance cDC migration and T helper 2 (Th2) differentiation. We explore the potential regulatory mechanisms of cDC migration in type 2 immunity, offering insights into the differential control of cDC trafficking in diverse immune contexts and its impact on immune responses.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558228/fulldendritic cell migrationtype 2 immune responsesCCR7cysteinyl leukotrienes (cysLTs)sphingosine-1-phosphate (S1P)7α,25-Dihydroxycholesterol (7α,25-OHC) |
| spellingShingle | Audrey Meloun Audrey Meloun Beatriz León Beyond CCR7: dendritic cell migration in type 2 inflammation Frontiers in Immunology dendritic cell migration type 2 immune responses CCR7 cysteinyl leukotrienes (cysLTs) sphingosine-1-phosphate (S1P) 7α,25-Dihydroxycholesterol (7α,25-OHC) |
| title | Beyond CCR7: dendritic cell migration in type 2 inflammation |
| title_full | Beyond CCR7: dendritic cell migration in type 2 inflammation |
| title_fullStr | Beyond CCR7: dendritic cell migration in type 2 inflammation |
| title_full_unstemmed | Beyond CCR7: dendritic cell migration in type 2 inflammation |
| title_short | Beyond CCR7: dendritic cell migration in type 2 inflammation |
| title_sort | beyond ccr7 dendritic cell migration in type 2 inflammation |
| topic | dendritic cell migration type 2 immune responses CCR7 cysteinyl leukotrienes (cysLTs) sphingosine-1-phosphate (S1P) 7α,25-Dihydroxycholesterol (7α,25-OHC) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558228/full |
| work_keys_str_mv | AT audreymeloun beyondccr7dendriticcellmigrationintype2inflammation AT audreymeloun beyondccr7dendriticcellmigrationintype2inflammation AT beatrizleon beyondccr7dendriticcellmigrationintype2inflammation |