Preoperative plasma cell-free DNA chromosomal instability predicts microvascular invasion in hepatocellular carcinoma: a prospective study

Preoperative plasma cell-free DNA chromosomal instability predicts microvascular invasion in hepatocellular carcinoma: a prospective study

Abstract Background Microvascular invasion (MVI) has been recognized as a risk factor for early recurrence after hepatectomy in patients with hepatocellular carcinoma (HCC). This study aimed to estimate the performance of an ultrasensitive chromosomal aneuploidy detector (UCAD) model for preoperativ...

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Bibliographic Details
Main Authors: Zheyue Shu, Ting Ye, Wei Wu, Menghan Su, Jingcheng Wang, Min Zhang, Ziliang Qian, Haifen Huang, Shusen Zheng, Qi Xia
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Microvascular invasion
Cell-free DNA
Low-coverage whole-genome sequencing
Ultrasensitive chromosomal aneuploidy detector model
Online Access:https://doi.org/10.1186/s12885-025-14268-9
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