Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study
BackgroundSepsis-associated acute kidney injury (SA-AKI) carries a disproportionately high morbidity and mortality rate. While the synergism between dysregulated host response and renal vulnerability is increasingly recognized, the multifactorial drivers of poor prognosis remain poorly defined. The...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1509180/full |
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| author | Panpan Jin Xihan Meng Chao Yu Cong Zhou |
| author_facet | Panpan Jin Xihan Meng Chao Yu Cong Zhou |
| author_sort | Panpan Jin |
| collection | DOAJ |
| description | BackgroundSepsis-associated acute kidney injury (SA-AKI) carries a disproportionately high morbidity and mortality rate. While the synergism between dysregulated host response and renal vulnerability is increasingly recognized, the multifactorial drivers of poor prognosis remain poorly defined. The purpose of this study was to investigate the prognosis and clinical characteristics of patients with pathogenic microorganism-positive SA-AKI.MethodUsing a retrospective analysis approach, we extracted populations from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database that fulfilled the diagnostic criteria for confirmed sepsis with microbiological evidence of pathogenic organisms, and patients were divided into two cohorts according to with or without AKI. The severity of the disease in the two groups was collected for evaluation, and the clinical indicators and prognostic results of the patients were evaluated. The objective of this study was to explore the risk factors affecting the prognosis of patients with pathogenic microorganism-positive SA-AKI.OutcomeThe hospital mortality rate of AKI in patients with pathogenic microbial-positive sepsis was 18.96%. Further analysis showed that the use of vasoactive drug therapy, high lactate level, SAPS II score, SAPS III score, LODS score, and clinical indicators of prolonged hospital stay were independent risk factors for in-hospital mortality in patients with pathogenic microorganism-positive SA-AKI. Among them, SAPS III score plays an important role in predicting the prognosis of sepsis patients with AKI. Further studies found that lactate level was positively correlated with SAPS II score, SAPS III score, and LODS score.ConclusionThe use of vasoactive drug therapy, high lactate level, SAPS II score, SAPS III score, and LODS score plays an important role in assessing the prognosis of patients with pathogenic microorganism-positive SA-AKI, and multivariate comprehensive assessment is significant in predicting the prognosis of sepsis AKI patients. |
| format | Article |
| id | doaj-art-516feae5e31748e2b8ce217f3d7d9987 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-516feae5e31748e2b8ce217f3d7d99872025-08-20T03:10:06ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-05-011510.3389/fcimb.2025.15091801509180Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort studyPanpan Jin0Xihan Meng1Chao Yu2Cong Zhou3Department of Nephrology and Immunology, Kaifeng Central Hospital, Kaifeng, Henan, ChinaZhongshan Clinical College, Dalian University, Dalian, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen, ChinaBackgroundSepsis-associated acute kidney injury (SA-AKI) carries a disproportionately high morbidity and mortality rate. While the synergism between dysregulated host response and renal vulnerability is increasingly recognized, the multifactorial drivers of poor prognosis remain poorly defined. The purpose of this study was to investigate the prognosis and clinical characteristics of patients with pathogenic microorganism-positive SA-AKI.MethodUsing a retrospective analysis approach, we extracted populations from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database that fulfilled the diagnostic criteria for confirmed sepsis with microbiological evidence of pathogenic organisms, and patients were divided into two cohorts according to with or without AKI. The severity of the disease in the two groups was collected for evaluation, and the clinical indicators and prognostic results of the patients were evaluated. The objective of this study was to explore the risk factors affecting the prognosis of patients with pathogenic microorganism-positive SA-AKI.OutcomeThe hospital mortality rate of AKI in patients with pathogenic microbial-positive sepsis was 18.96%. Further analysis showed that the use of vasoactive drug therapy, high lactate level, SAPS II score, SAPS III score, LODS score, and clinical indicators of prolonged hospital stay were independent risk factors for in-hospital mortality in patients with pathogenic microorganism-positive SA-AKI. Among them, SAPS III score plays an important role in predicting the prognosis of sepsis patients with AKI. Further studies found that lactate level was positively correlated with SAPS II score, SAPS III score, and LODS score.ConclusionThe use of vasoactive drug therapy, high lactate level, SAPS II score, SAPS III score, and LODS score plays an important role in assessing the prognosis of patients with pathogenic microorganism-positive SA-AKI, and multivariate comprehensive assessment is significant in predicting the prognosis of sepsis AKI patients.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1509180/fullpositive for pathogenic microorganismssepsisacute kidney injury (AKI)prognosisSAPS IIIrisk factors |
| spellingShingle | Panpan Jin Xihan Meng Chao Yu Cong Zhou Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study Frontiers in Cellular and Infection Microbiology positive for pathogenic microorganisms sepsis acute kidney injury (AKI) prognosis SAPS III risk factors |
| title | Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study |
| title_full | Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study |
| title_fullStr | Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study |
| title_full_unstemmed | Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study |
| title_short | Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study |
| title_sort | characteristics and prognosis of patients with pathogenic microorganism positive sepsis aki from icu a retrospective cohort study |
| topic | positive for pathogenic microorganisms sepsis acute kidney injury (AKI) prognosis SAPS III risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1509180/full |
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