Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction
Objective: The objective of this study was to investigate the changes in health-related quality of life (HRQoL) and motor and depressive symptoms in patients with Parkinson's disease (PD) from baseline to 12 months following subthalamic nucleus deep brain stimulation (STN-DBS). Materials and Me...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=107;epage=112;aulast=Jiang |
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| author | Jiin-Ling Jiang Shin-Yuan Chen Sheng-Tzung Tsai |
| author_facet | Jiin-Ling Jiang Shin-Yuan Chen Sheng-Tzung Tsai |
| author_sort | Jiin-Ling Jiang |
| collection | DOAJ |
| description | Objective: The objective of this study was to investigate the changes in health-related quality of life (HRQoL) and motor and depressive symptoms in patients with Parkinson's disease (PD) from baseline to 12 months following subthalamic nucleus deep brain stimulation (STN-DBS). Materials and Methods: The study utilized a prospective observational cohort design. Thirty-three PD patients with a good levodopa response but drug-related morbidity were included. PD Questionnaire-39 (PDQ-39) scores, unified PD rating scale (UPDRS) scores, Hoehn and Yahr stages, Beck Depression Inventory-II scores, and levodopa equivalent daily doses (LEDD) were obtained at baseline and 1 year after surgery. Results: The enrolled patients showed a significant HRQoL improvement of 21.43% at 12 months after STN-DBS as assessed by the PDQ-39 total score. There was a 34.92% improvement in UPDRS scores after STN-DBS at 1 year follow-up. Subitem analysis revealed significant improvement in UPDRS part II, III, and IV scores. The LEDD was significantly reduced by up to 27.36% 12 months after surgery. The preoperative PDQ-39 total score and LEDD predicted postoperative HRQoL in PD following STN-DBS. Conclusions: The current study demonstrated that STN-DBS surgery significantly improved HRQoL and motor outcomes of patients with PD. The preoperative PDQ-39 score and LEDD were predictors of the efficacy of postoperative HRQoL following surgery. |
| format | Article |
| id | doaj-art-516fd33981e643f0bb55fa573a68acf4 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-516fd33981e643f0bb55fa573a68acf42025-08-20T02:12:58ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562019-01-0131210711210.4103/tcmj.tcmj_92_18Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome predictionJiin-Ling JiangShin-Yuan ChenSheng-Tzung TsaiObjective: The objective of this study was to investigate the changes in health-related quality of life (HRQoL) and motor and depressive symptoms in patients with Parkinson's disease (PD) from baseline to 12 months following subthalamic nucleus deep brain stimulation (STN-DBS). Materials and Methods: The study utilized a prospective observational cohort design. Thirty-three PD patients with a good levodopa response but drug-related morbidity were included. PD Questionnaire-39 (PDQ-39) scores, unified PD rating scale (UPDRS) scores, Hoehn and Yahr stages, Beck Depression Inventory-II scores, and levodopa equivalent daily doses (LEDD) were obtained at baseline and 1 year after surgery. Results: The enrolled patients showed a significant HRQoL improvement of 21.43% at 12 months after STN-DBS as assessed by the PDQ-39 total score. There was a 34.92% improvement in UPDRS scores after STN-DBS at 1 year follow-up. Subitem analysis revealed significant improvement in UPDRS part II, III, and IV scores. The LEDD was significantly reduced by up to 27.36% 12 months after surgery. The preoperative PDQ-39 total score and LEDD predicted postoperative HRQoL in PD following STN-DBS. Conclusions: The current study demonstrated that STN-DBS surgery significantly improved HRQoL and motor outcomes of patients with PD. The preoperative PDQ-39 score and LEDD were predictors of the efficacy of postoperative HRQoL following surgery.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=107;epage=112;aulast=JiangDeep brain stimulationParkinson's diseaseQuality of lifeSubthalamic nucleus |
| spellingShingle | Jiin-Ling Jiang Shin-Yuan Chen Sheng-Tzung Tsai Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction Tzu Chi Medical Journal Deep brain stimulation Parkinson's disease Quality of life Subthalamic nucleus |
| title | Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction |
| title_full | Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction |
| title_fullStr | Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction |
| title_full_unstemmed | Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction |
| title_short | Quality of life in patients with Parkinson's disease after subthalamic stimulation: An observational cohort study for outcome prediction |
| title_sort | quality of life in patients with parkinson s disease after subthalamic stimulation an observational cohort study for outcome prediction |
| topic | Deep brain stimulation Parkinson's disease Quality of life Subthalamic nucleus |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=107;epage=112;aulast=Jiang |
| work_keys_str_mv | AT jiinlingjiang qualityoflifeinpatientswithparkinsonsdiseaseaftersubthalamicstimulationanobservationalcohortstudyforoutcomeprediction AT shinyuanchen qualityoflifeinpatientswithparkinsonsdiseaseaftersubthalamicstimulationanobservationalcohortstudyforoutcomeprediction AT shengtzungtsai qualityoflifeinpatientswithparkinsonsdiseaseaftersubthalamicstimulationanobservationalcohortstudyforoutcomeprediction |