The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt
Abstract Introduction Real-world data on atrial fibrillation (AF) in the Middle East and North Africa (MENA) region, including Egypt, are sparse. The aim of the FLOW-AF registry was to evaluate the characteristics, treatment patterns, and clinical and economic outcomes of newly diagnosed non-valvula...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2025-03-01
|
| Series: | Cardiology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40119-025-00400-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849733827143925760 |
|---|---|
| author | Mohamed Sobhy Magdy Abdelhamid Adel Mohamed El Etriby Mohamed Fathy Soliman Gamaleldin Ahmed Mohamed Helmy Youssef Natasha Khalife Hany Ragy Ashraf Reda Maichel Sobhy Mostafa Nawar |
| author_facet | Mohamed Sobhy Magdy Abdelhamid Adel Mohamed El Etriby Mohamed Fathy Soliman Gamaleldin Ahmed Mohamed Helmy Youssef Natasha Khalife Hany Ragy Ashraf Reda Maichel Sobhy Mostafa Nawar |
| author_sort | Mohamed Sobhy |
| collection | DOAJ |
| description | Abstract Introduction Real-world data on atrial fibrillation (AF) in the Middle East and North Africa (MENA) region, including Egypt, are sparse. The aim of the FLOW-AF registry was to evaluate the characteristics, treatment patterns, and clinical and economic outcomes of newly diagnosed non-valvular atrial fibrillation (NVAF) patients within the MENA region, including Egypt. Methods This multicenter, prospective, observational registry enrolled newly diagnosed patients with NVAF from January 2020 to December 2022 at eight private-sector healthcare centers in Egypt. Data were collected at enrollment (baseline), and then at 6-month and 12-month follow-up. Baseline data included demographics, AF characteristics, medical history, and antithrombotic treatment patterns. Follow-up data included clinical events, healthcare resource utilization, and related costs. Results A total of 723 patients were enrolled. Overall, 51.87% were females, and the mean age was 61.9 years. All patients attended the private health sector. The mean (standard deviation) CHA2DS2-VASc and HAS-BLED risk scores were 2.37 (1.55) and 1.46 (1.18), respectively. Non-vitamin K antagonist oral anticoagulants (62.52%), vitamin K antagonists (22.28%), and antiplatelet therapy (9.85%) were among the prescribed treatments. Rates of transient ischemic attack and all-cause mortality were 2.64% and 0.83%, respectively; all other outcomes (stroke, bleeding, myocardial infarction, systemic embolism) occurred at a rate of ≤ 0.41%. Antithrombotic medications were the major contributors to per-patient total yearly cost (USD 381.2). Conclusions The FLOW-AF study showed that patients with NVAF in Egypt are younger and exhibit lower mean baseline CHA2DS2-VASc and HAS-BLED scores compared to Western and other Eastern regions. Additional research, including a broader study population with a longer follow-up, is essential to comprehensively assess the characteristics and outcomes of the NVAF population in Egypt. |
| format | Article |
| id | doaj-art-516ddb3a0731492ba219e2ca81160ffb |
| institution | DOAJ |
| issn | 2193-8261 2193-6544 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Cardiology and Therapy |
| spelling | doaj-art-516ddb3a0731492ba219e2ca81160ffb2025-08-20T03:07:57ZengAdis, Springer HealthcareCardiology and Therapy2193-82612193-65442025-03-0114216118210.1007/s40119-025-00400-0The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in EgyptMohamed Sobhy0Magdy Abdelhamid1Adel Mohamed El Etriby2Mohamed Fathy Soliman Gamaleldin3Ahmed Mohamed Helmy Youssef4Natasha Khalife5Hany Ragy6Ashraf Reda7Maichel Sobhy8Mostafa Nawar9International Cardiac Center HospitalPrivate ClinicPrivate ClinicPfizer GulfPfizer EgyptDubai World Trade Center, IQVIA, Real-World EvidenceCardiocath Medical Private CenterPrivate ClinicPrivate Clinic, Cairo UniversityPrivate ClinicAbstract Introduction Real-world data on atrial fibrillation (AF) in the Middle East and North Africa (MENA) region, including Egypt, are sparse. The aim of the FLOW-AF registry was to evaluate the characteristics, treatment patterns, and clinical and economic outcomes of newly diagnosed non-valvular atrial fibrillation (NVAF) patients within the MENA region, including Egypt. Methods This multicenter, prospective, observational registry enrolled newly diagnosed patients with NVAF from January 2020 to December 2022 at eight private-sector healthcare centers in Egypt. Data were collected at enrollment (baseline), and then at 6-month and 12-month follow-up. Baseline data included demographics, AF characteristics, medical history, and antithrombotic treatment patterns. Follow-up data included clinical events, healthcare resource utilization, and related costs. Results A total of 723 patients were enrolled. Overall, 51.87% were females, and the mean age was 61.9 years. All patients attended the private health sector. The mean (standard deviation) CHA2DS2-VASc and HAS-BLED risk scores were 2.37 (1.55) and 1.46 (1.18), respectively. Non-vitamin K antagonist oral anticoagulants (62.52%), vitamin K antagonists (22.28%), and antiplatelet therapy (9.85%) were among the prescribed treatments. Rates of transient ischemic attack and all-cause mortality were 2.64% and 0.83%, respectively; all other outcomes (stroke, bleeding, myocardial infarction, systemic embolism) occurred at a rate of ≤ 0.41%. Antithrombotic medications were the major contributors to per-patient total yearly cost (USD 381.2). Conclusions The FLOW-AF study showed that patients with NVAF in Egypt are younger and exhibit lower mean baseline CHA2DS2-VASc and HAS-BLED scores compared to Western and other Eastern regions. Additional research, including a broader study population with a longer follow-up, is essential to comprehensively assess the characteristics and outcomes of the NVAF population in Egypt.https://doi.org/10.1007/s40119-025-00400-0Atrial fibrillationClinical outcomesEgyptHealthcare resource utilizationOral anticoagulants |
| spellingShingle | Mohamed Sobhy Magdy Abdelhamid Adel Mohamed El Etriby Mohamed Fathy Soliman Gamaleldin Ahmed Mohamed Helmy Youssef Natasha Khalife Hany Ragy Ashraf Reda Maichel Sobhy Mostafa Nawar The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt Cardiology and Therapy Atrial fibrillation Clinical outcomes Egypt Healthcare resource utilization Oral anticoagulants |
| title | The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt |
| title_full | The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt |
| title_fullStr | The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt |
| title_full_unstemmed | The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt |
| title_short | The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt |
| title_sort | atrial fibrillation registry flow af patient characteristics treatment patterns and outcomes in egypt |
| topic | Atrial fibrillation Clinical outcomes Egypt Healthcare resource utilization Oral anticoagulants |
| url | https://doi.org/10.1007/s40119-025-00400-0 |
| work_keys_str_mv | AT mohamedsobhy theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT magdyabdelhamid theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT adelmohamedeletriby theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT mohamedfathysolimangamaleldin theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT ahmedmohamedhelmyyoussef theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT natashakhalife theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT hanyragy theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT ashrafreda theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT maichelsobhy theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT mostafanawar theatrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT mohamedsobhy atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT magdyabdelhamid atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT adelmohamedeletriby atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT mohamedfathysolimangamaleldin atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT ahmedmohamedhelmyyoussef atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT natashakhalife atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT hanyragy atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT ashrafreda atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT maichelsobhy atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt AT mostafanawar atrialfibrillationregistryflowafpatientcharacteristicstreatmentpatternsandoutcomesinegypt |