Characterization of Klebsiella pneumoniae carbapenemase (KPC)-14, a KPC variant conferring resistance to ceftazidime-avibactam in the extensively drug-resistant ST463 Pseudomonas aeruginosa clinical isolate

Characterization of Klebsiella pneumoniae carbapenemase (KPC)-14, a KPC variant conferring resistance to ceftazidime-avibactam in the extensively drug-resistant ST463 Pseudomonas aeruginosa clinical isolate

Objective: We studied two Klebsiella pneumoniae carbapenemase (KPC)-14 variants from clinical Pseudomonas aeruginosa isolates (C137 and C159) to better understand the genomic diversity, mechanisms, and genes that confer antibiotic resistance and pathogenicity. Methods: Genomic DNA from C137/159 was...

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Bibliographic Details
Main Authors: Yanyan Xiao, Le Wang, Huiqiong Jia, Yan Jiang, Yue Li, Jiamin Han, Shengchao Li, Yaxi Gu, Qing Yang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
blakpc-14
Carbapenemase-producing Pseudomonas aeruginosa
Ceftazidime-avibactam-resistant
XDR-PA
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716525000645
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