Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology.
<h4>Objectives</h4>It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with hea...
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Public Library of Science (PLoS)
2016-01-01
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| author | Theresia M Schnurr Anette P Gjesing Camilla H Sandholt Anna Jonsson Yuvaraj Mahendran Christian T Have Claus T Ekstrøm Anne-Louise Bjerregaard Soren Brage Daniel R Witte Marit E Jørgensen Mette Aadahl Betina H Thuesen Allan Linneberg Hans Eiberg Oluf Pedersen Niels Grarup Tuomas O Kilpeläinen Torben Hansen |
| author_facet | Theresia M Schnurr Anette P Gjesing Camilla H Sandholt Anna Jonsson Yuvaraj Mahendran Christian T Have Claus T Ekstrøm Anne-Louise Bjerregaard Soren Brage Daniel R Witte Marit E Jørgensen Mette Aadahl Betina H Thuesen Allan Linneberg Hans Eiberg Oluf Pedersen Niels Grarup Tuomas O Kilpeläinen Torben Hansen |
| author_sort | Theresia M Schnurr |
| collection | DOAJ |
| description | <h4>Objectives</h4>It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF.<h4>Methods</h4>Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition.<h4>Results</h4>We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM.<h4>Conclusions</h4>Our findings suggest a shared genetic etiology between whole body fat% and CRF. |
| format | Article |
| id | doaj-art-5167aa16afca4b0ca07d847cb7bb0bfc |
| institution | Kabale University |
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| language | English |
| publishDate | 2016-01-01 |
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| spelling | doaj-art-5167aa16afca4b0ca07d847cb7bb0bfc2025-08-20T03:26:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016673810.1371/journal.pone.0166738Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology.Theresia M SchnurrAnette P GjesingCamilla H SandholtAnna JonssonYuvaraj MahendranChristian T HaveClaus T EkstrømAnne-Louise BjerregaardSoren BrageDaniel R WitteMarit E JørgensenMette AadahlBetina H ThuesenAllan LinnebergHans EibergOluf PedersenNiels GrarupTuomas O KilpeläinenTorben Hansen<h4>Objectives</h4>It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF.<h4>Methods</h4>Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition.<h4>Results</h4>We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM.<h4>Conclusions</h4>Our findings suggest a shared genetic etiology between whole body fat% and CRF.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0166738&type=printable |
| spellingShingle | Theresia M Schnurr Anette P Gjesing Camilla H Sandholt Anna Jonsson Yuvaraj Mahendran Christian T Have Claus T Ekstrøm Anne-Louise Bjerregaard Soren Brage Daniel R Witte Marit E Jørgensen Mette Aadahl Betina H Thuesen Allan Linneberg Hans Eiberg Oluf Pedersen Niels Grarup Tuomas O Kilpeläinen Torben Hansen Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. PLoS ONE |
| title | Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. |
| title_full | Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. |
| title_fullStr | Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. |
| title_full_unstemmed | Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. |
| title_short | Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. |
| title_sort | genetic correlation between body fat percentage and cardiorespiratory fitness suggests common genetic etiology |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0166738&type=printable |
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