Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis
This study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1949486 |
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| author | Yanhui Gu Ying Zhang Qian Wen Yao Ouyang Yongchun Shen He Yu Chun Wan Jing Zhu Fuqiang Wen |
| author_facet | Yanhui Gu Ying Zhang Qian Wen Yao Ouyang Yongchun Shen He Yu Chun Wan Jing Zhu Fuqiang Wen |
| author_sort | Yanhui Gu |
| collection | DOAJ |
| description | This study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects aged ≥40 years who underwent a health examination, both lung function and COPD-PS data were collected. The screening performance of COPD-PS was evaluated with a receiver operating characteristic (ROC) curve analysis, using the area under the curve (AUC) to assess the screening accuracy. A standard diagnostic meta-analysis was used to summarise the screening performance of COPD-PS for COPD. Of the 997 subjects, 157 were identified as having COPD. The COPD-PS score was significantly higher in COPD patients than controls (5.03 ± 5.11 vs. 2.72 ± 1.80, p < .001). At a cut-off of 4, the sensitivity and specificity of COPD-PS for identifying COPD were 74.52 and 70.24%, respectively, with an AUC of 0.79. Eight studies (including this study) were included in this meta-analysis. The pooled estimates for COPD-PS were as follows: sensitivity of 0.66 (95% CI: 0.47–0.63), specificity of 0.86 (95% CI: 0.84–0.89), positive likelihood ratio of 3.00 (95% CI: 1.65–5.47), negative likelihood ratio of 0.43 (95% CI: 0.35–0.52) and diagnostic odds ratio of 7.24 (95% CI: 3.91–13.40). The AUC of the summary ROC curve was 0.78. COPD-PS appears to be a useful tool for screening individuals with a high risk of COPD and guiding the selection of individuals for subsequent spirometry examination.KEY MESSAGESCOPD-PS is a simple and useful method to screen COPD.The combination of COPD-PS with other tools may improve the screen performance. |
| format | Article |
| id | doaj-art-5166f8d8f79f411bbdd499c9699c965f |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-5166f8d8f79f411bbdd499c9699c965f2025-08-20T03:43:55ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015311199120710.1080/07853890.2021.1949486Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysisYanhui Gu0Ying Zhang1Qian Wen2Yao Ouyang3Yongchun Shen4He Yu5Chun Wan6Jing Zhu7Fuqiang Wen8Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaHealth Management Center, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaThis study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects aged ≥40 years who underwent a health examination, both lung function and COPD-PS data were collected. The screening performance of COPD-PS was evaluated with a receiver operating characteristic (ROC) curve analysis, using the area under the curve (AUC) to assess the screening accuracy. A standard diagnostic meta-analysis was used to summarise the screening performance of COPD-PS for COPD. Of the 997 subjects, 157 were identified as having COPD. The COPD-PS score was significantly higher in COPD patients than controls (5.03 ± 5.11 vs. 2.72 ± 1.80, p < .001). At a cut-off of 4, the sensitivity and specificity of COPD-PS for identifying COPD were 74.52 and 70.24%, respectively, with an AUC of 0.79. Eight studies (including this study) were included in this meta-analysis. The pooled estimates for COPD-PS were as follows: sensitivity of 0.66 (95% CI: 0.47–0.63), specificity of 0.86 (95% CI: 0.84–0.89), positive likelihood ratio of 3.00 (95% CI: 1.65–5.47), negative likelihood ratio of 0.43 (95% CI: 0.35–0.52) and diagnostic odds ratio of 7.24 (95% CI: 3.91–13.40). The AUC of the summary ROC curve was 0.78. COPD-PS appears to be a useful tool for screening individuals with a high risk of COPD and guiding the selection of individuals for subsequent spirometry examination.KEY MESSAGESCOPD-PS is a simple and useful method to screen COPD.The combination of COPD-PS with other tools may improve the screen performance.https://www.tandfonline.com/doi/10.1080/07853890.2021.1949486Chronic obstructive pulmonary diseasechronic obstructive pulmonary disease population screenerscreeningmeta-analysis |
| spellingShingle | Yanhui Gu Ying Zhang Qian Wen Yao Ouyang Yongchun Shen He Yu Chun Wan Jing Zhu Fuqiang Wen Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis Annals of Medicine Chronic obstructive pulmonary disease chronic obstructive pulmonary disease population screener screening meta-analysis |
| title | Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis |
| title_full | Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis |
| title_fullStr | Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis |
| title_full_unstemmed | Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis |
| title_short | Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis |
| title_sort | performance of copd population screener questionnaire in copd screening a validation study and meta analysis |
| topic | Chronic obstructive pulmonary disease chronic obstructive pulmonary disease population screener screening meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1949486 |
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