Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity

Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity

Abstract Scalable approaches for enhancing therapeutic small extracellular vesicles (sEVs) production can facilitate the transition of sEVs from bench to bedside and beyond. Here, we present a user-friendly method to manipulate the extracellular mechanical microenvironment of umbilical cord-derived...

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Bibliographic Details
Main Authors: Chengmeng Bai, Huifang Ren, Feng Zhang, Dandan Li, Qingyu Feng, Ying Li, Ting Chen, Chengxu Li, Xuan Xiao, Hengrui Zhang, Liang Hu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stem cells
Extracellular vesicles
Mechanical stimulation
Corneal healing
Tissue regeneration
Online Access:https://doi.org/10.1186/s12951-025-03556-y
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