Molecular basis of D-negative phenotype (literature review and case reports)
The molecular basis of the D-negative phenotype formation in humans is presented in this article. Causes of true and false D-negative phenotype appearance are described. The basis of true D-negative phenotype are changes in the genome, that lead to complete lack of RhD antigen expression on the red...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-10-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/155 |
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| author | L. L. Golovkina A. G. Stremouchova T. D. Pushkina B. B. Khasigova G. V. Atroshchenko M. N. Vasilyeva R. S. Kalandarov E. N. Parovichnikova |
| author_facet | L. L. Golovkina A. G. Stremouchova T. D. Pushkina B. B. Khasigova G. V. Atroshchenko M. N. Vasilyeva R. S. Kalandarov E. N. Parovichnikova |
| author_sort | L. L. Golovkina |
| collection | DOAJ |
| description | The molecular basis of the D-negative phenotype formation in humans is presented in this article. Causes of true and false D-negative phenotype appearance are described. The basis of true D-negative phenotype are changes in the genome, that lead to complete lack of RhD antigen expression on the red blood cells surface, or defective expression of RhD antigen, not detectable by serological methods. The reason for the false D-negative phenotype is the insufficient sensitivity of routine serological methods. Cases of true and false D-negative phenotype identified during the examination of the Russia residents are described. We were able to identify one case of true (RHDψ) and five cases of false D-negative phenotype (RHD weak type 2 – two cases, RHD weak type 15 – one case and RHD weak type 20 – two cases) by molecular method. |
| format | Article |
| id | doaj-art-5155e2e367e04f5aa305f2e3fcabc293 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-5155e2e367e04f5aa305f2e3fcabc2932025-08-20T04:00:14ZrusABV-pressОнкогематология1818-83462413-40232015-10-01103646910.17650/1818-8346-2015-10-3-64-69169Molecular basis of D-negative phenotype (literature review and case reports)L. L. Golovkina0A. G. Stremouchova1T. D. Pushkina2B. B. Khasigova3G. V. Atroshchenko4M. N. Vasilyeva5R. S. Kalandarov6E. N. Parovichnikova7Hematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaHematological Research Center, Ministry of Health of RussiaThe molecular basis of the D-negative phenotype formation in humans is presented in this article. Causes of true and false D-negative phenotype appearance are described. The basis of true D-negative phenotype are changes in the genome, that lead to complete lack of RhD antigen expression on the red blood cells surface, or defective expression of RhD antigen, not detectable by serological methods. The reason for the false D-negative phenotype is the insufficient sensitivity of routine serological methods. Cases of true and false D-negative phenotype identified during the examination of the Russia residents are described. We were able to identify one case of true (RHDψ) and five cases of false D-negative phenotype (RHD weak type 2 – two cases, RHD weak type 15 – one case and RHD weak type 20 – two cases) by molecular method.https://oncohematology.abvpress.ru/ongm/article/view/155genegenotypephenotyperhesusrhesus complexalloimmunizationtrue negative d-phenotypefalse negative d-phenotypeallelesmutationserythrocyte antigens |
| spellingShingle | L. L. Golovkina A. G. Stremouchova T. D. Pushkina B. B. Khasigova G. V. Atroshchenko M. N. Vasilyeva R. S. Kalandarov E. N. Parovichnikova Molecular basis of D-negative phenotype (literature review and case reports) Онкогематология gene genotype phenotype rhesus rhesus complex alloimmunization true negative d-phenotype false negative d-phenotype alleles mutations erythrocyte antigens |
| title | Molecular basis of D-negative phenotype (literature review and case reports) |
| title_full | Molecular basis of D-negative phenotype (literature review and case reports) |
| title_fullStr | Molecular basis of D-negative phenotype (literature review and case reports) |
| title_full_unstemmed | Molecular basis of D-negative phenotype (literature review and case reports) |
| title_short | Molecular basis of D-negative phenotype (literature review and case reports) |
| title_sort | molecular basis of d negative phenotype literature review and case reports |
| topic | gene genotype phenotype rhesus rhesus complex alloimmunization true negative d-phenotype false negative d-phenotype alleles mutations erythrocyte antigens |
| url | https://oncohematology.abvpress.ru/ongm/article/view/155 |
| work_keys_str_mv | AT llgolovkina molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT agstremouchova molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT tdpushkina molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT bbkhasigova molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT gvatroshchenko molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT mnvasilyeva molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT rskalandarov molecularbasisofdnegativephenotypeliteraturereviewandcasereports AT enparovichnikova molecularbasisofdnegativephenotypeliteraturereviewandcasereports |