Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study
Background: We aimed to determine if serum cholesterol and body mass index (BMI), which are important in maintaining immunity, have any impact on the radiological severity in patients with drug-resistant pulmonary tuberculosis (DR-TB). Materials and Methods: A cross-sectional pilot study was conduct...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-04-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/INJMS.INJMS_1_19 |
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| author | Alam Nawaz Manel Arjun Nayak Subhangi Thakur Hameer Ashwin Kamath Ajit Mahale |
| author_facet | Alam Nawaz Manel Arjun Nayak Subhangi Thakur Hameer Ashwin Kamath Ajit Mahale |
| author_sort | Alam Nawaz |
| collection | DOAJ |
| description | Background:
We aimed to determine if serum cholesterol and body mass index (BMI), which are important in maintaining immunity, have any impact on the radiological severity in patients with drug-resistant pulmonary tuberculosis (DR-TB).
Materials and Methods:
A cross-sectional pilot study was conducted over 2 years in adults with newly diagnosed DR-TB. The radiological severity of the disease was determined using a chest X-ray (CXR) scoring formula. Correlation between the lipid fraction levels, BMI, and the CXR scores was determined using Pearson's correlation coefficient.
Results:
Thirty-three patients were included in the study. A significant negative correlation was seen between the CXR severity scores and total cholesterol (r = −0.546,P = 0.001), high-density lipoprotein-cholesterol (r = −0.479,P = 0.005), low-density lipoprotein-cholesterol (r = −0.431,P = 0.012), and BMI (r = −0.352,P = 0.044).
Conclusions:
Low serum cholesterol levels and low BMI were associated with an increased radiological severity which, in turn, could result in increased infectivity. Adequate nutritional supplementation in the diet of patients to increase BMI, and serum cholesterol levels, could potentially decrease the severity, and also consequently, transmission, and incidence of DR-TB. |
| format | Article |
| id | doaj-art-5154b7b1fa3b4e71a6648b7feb76aecf |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-5154b7b1fa3b4e71a6648b7feb76aecf2025-08-25T08:30:58ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922019-04-011029910410.4103/INJMS.INJMS_1_19Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot StudyAlam NawazManel Arjun NayakSubhangi Thakur HameerAshwin KamathAjit MahaleBackground: We aimed to determine if serum cholesterol and body mass index (BMI), which are important in maintaining immunity, have any impact on the radiological severity in patients with drug-resistant pulmonary tuberculosis (DR-TB). Materials and Methods: A cross-sectional pilot study was conducted over 2 years in adults with newly diagnosed DR-TB. The radiological severity of the disease was determined using a chest X-ray (CXR) scoring formula. Correlation between the lipid fraction levels, BMI, and the CXR scores was determined using Pearson's correlation coefficient. Results: Thirty-three patients were included in the study. A significant negative correlation was seen between the CXR severity scores and total cholesterol (r = −0.546,P = 0.001), high-density lipoprotein-cholesterol (r = −0.479,P = 0.005), low-density lipoprotein-cholesterol (r = −0.431,P = 0.012), and BMI (r = −0.352,P = 0.044). Conclusions: Low serum cholesterol levels and low BMI were associated with an increased radiological severity which, in turn, could result in increased infectivity. Adequate nutritional supplementation in the diet of patients to increase BMI, and serum cholesterol levels, could potentially decrease the severity, and also consequently, transmission, and incidence of DR-TB.https://journals.lww.com/10.4103/INJMS.INJMS_1_19cholesteroldrug-resistant tuberculosisinfection transmissionradiography |
| spellingShingle | Alam Nawaz Manel Arjun Nayak Subhangi Thakur Hameer Ashwin Kamath Ajit Mahale Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study Indian Journal of Medical Specialities cholesterol drug-resistant tuberculosis infection transmission radiography |
| title | Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study |
| title_full | Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study |
| title_fullStr | Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study |
| title_full_unstemmed | Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study |
| title_short | Correlation between Serum Lipid Fractions and Radiological Severity in Patients with Drug-Resistant Pulmonary Tuberculosis: A Cross-Sectional Pilot Study |
| title_sort | correlation between serum lipid fractions and radiological severity in patients with drug resistant pulmonary tuberculosis a cross sectional pilot study |
| topic | cholesterol drug-resistant tuberculosis infection transmission radiography |
| url | https://journals.lww.com/10.4103/INJMS.INJMS_1_19 |
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