Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2024-09-01
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| Series: | JACS Au |
| Online Access: | https://doi.org/10.1021/jacsau.4c00477 |
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| _version_ | 1850082550242869248 |
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| author | Sabrina Collin Kira J. Weissman Arnaud Gruez |
| author_facet | Sabrina Collin Kira J. Weissman Arnaud Gruez |
| author_sort | Sabrina Collin |
| collection | DOAJ |
| format | Article |
| id | doaj-art-514cb42d8dbc484b9a67c9d2931e06e1 |
| institution | DOAJ |
| issn | 2691-3704 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | JACS Au |
| spelling | doaj-art-514cb42d8dbc484b9a67c9d2931e06e12025-08-20T02:44:29ZengAmerican Chemical SocietyJACS Au2691-37042024-09-014103833384710.1021/jacsau.4c00477Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate AccommodationSabrina CollinKira J. WeissmanArnaud Gruezhttps://doi.org/10.1021/jacsau.4c00477 |
| spellingShingle | Sabrina Collin Kira J. Weissman Arnaud Gruez Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation JACS Au |
| title | Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation |
| title_full | Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation |
| title_fullStr | Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation |
| title_full_unstemmed | Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation |
| title_short | Structural Plasticity within 3‑Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of β‑Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation |
| title_sort | structural plasticity within 3 hydroxy 3 methylglutaryl synthases catalyzing the first step of β branching in polyketide biosynthesis underpins a dynamic mechanism of substrate accommodation |
| url | https://doi.org/10.1021/jacsau.4c00477 |
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