Examining vaccination-related adverse events in frequent neurodegenerative diseases
This study investigates adverse events following vaccination in patients with four neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Multiple Sclerosis (MS), and Parkinson's disease. We applied advanced data processing techniques to analyze symptom patte...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624001807 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586194469257216 |
|---|---|
| author | Shabnam Sodagari Nassim Sodagari |
| author_facet | Shabnam Sodagari Nassim Sodagari |
| author_sort | Shabnam Sodagari |
| collection | DOAJ |
| description | This study investigates adverse events following vaccination in patients with four neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Multiple Sclerosis (MS), and Parkinson's disease. We applied advanced data processing techniques to analyze symptom patterns and severity scores across these disease groups. Patients were identified through filtering, and symptom clusters were extracted to group similar symptoms into distinct clusters, and severity scores were computed based on hospitalization and death reports. A chi-squared test was performed to assess the statistical significance of adverse event distributions among the diseases for different vaccines. The results reveal that ALS patients exhibit severe respiratory symptoms post-vaccination, while Alzheimer's patients report significant respiratory and gastrointestinal issues. MS patients commonly experience general symptoms such as fatigue, while Parkinson's patients face exacerbated motor symptoms. Notably, our analysis showed no significant difference in adverse event reporting rates between COVID-19 and pneumococcal vaccines across these disease groups. This research provides new insights into disease-specific responses to vaccines, emphasizing the importance of personalized monitoring and treatment strategies to mitigate risks and improve clinical outcomes in these vulnerable populations. |
| format | Article |
| id | doaj-art-5148b384bc8c4d72a537e3a6c0354ba4 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-5148b384bc8c4d72a537e3a6c0354ba42025-01-26T05:04:58ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-02-0143100902Examining vaccination-related adverse events in frequent neurodegenerative diseasesShabnam Sodagari0Nassim Sodagari1Computer Engineering and Computer Science Department, California State University, Long Beach, 90840, CA, USA; Corresponding author.Tehran University of Medical Sciences, IranThis study investigates adverse events following vaccination in patients with four neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Multiple Sclerosis (MS), and Parkinson's disease. We applied advanced data processing techniques to analyze symptom patterns and severity scores across these disease groups. Patients were identified through filtering, and symptom clusters were extracted to group similar symptoms into distinct clusters, and severity scores were computed based on hospitalization and death reports. A chi-squared test was performed to assess the statistical significance of adverse event distributions among the diseases for different vaccines. The results reveal that ALS patients exhibit severe respiratory symptoms post-vaccination, while Alzheimer's patients report significant respiratory and gastrointestinal issues. MS patients commonly experience general symptoms such as fatigue, while Parkinson's patients face exacerbated motor symptoms. Notably, our analysis showed no significant difference in adverse event reporting rates between COVID-19 and pneumococcal vaccines across these disease groups. This research provides new insights into disease-specific responses to vaccines, emphasizing the importance of personalized monitoring and treatment strategies to mitigate risks and improve clinical outcomes in these vulnerable populations.http://www.sciencedirect.com/science/article/pii/S2666354624001807Adverse eventsAmyotrophic lateral sclerosis (ALS)Alzheimer'sMultiple sclerosis (MS)Parkinson'sVaccination |
| spellingShingle | Shabnam Sodagari Nassim Sodagari Examining vaccination-related adverse events in frequent neurodegenerative diseases Brain, Behavior, & Immunity - Health Adverse events Amyotrophic lateral sclerosis (ALS) Alzheimer's Multiple sclerosis (MS) Parkinson's Vaccination |
| title | Examining vaccination-related adverse events in frequent neurodegenerative diseases |
| title_full | Examining vaccination-related adverse events in frequent neurodegenerative diseases |
| title_fullStr | Examining vaccination-related adverse events in frequent neurodegenerative diseases |
| title_full_unstemmed | Examining vaccination-related adverse events in frequent neurodegenerative diseases |
| title_short | Examining vaccination-related adverse events in frequent neurodegenerative diseases |
| title_sort | examining vaccination related adverse events in frequent neurodegenerative diseases |
| topic | Adverse events Amyotrophic lateral sclerosis (ALS) Alzheimer's Multiple sclerosis (MS) Parkinson's Vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624001807 |
| work_keys_str_mv | AT shabnamsodagari examiningvaccinationrelatedadverseeventsinfrequentneurodegenerativediseases AT nassimsodagari examiningvaccinationrelatedadverseeventsinfrequentneurodegenerativediseases |