The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types
Abstract The “Life’s Essential 8” (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk by optimizing lifestyle factors including diet, physical activity, and other health metrics. While individual components of LE8 hav...
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Nature Portfolio
2025-03-01
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| Online Access: | https://doi.org/10.1038/s41598-025-94009-x |
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| author | Wenzai Shi Yiming Wang Shuohua Chen Pengcheng Wei Delin Ma Jiye Zhu Qingsong Zhang Zhao Li |
| author_facet | Wenzai Shi Yiming Wang Shuohua Chen Pengcheng Wei Delin Ma Jiye Zhu Qingsong Zhang Zhao Li |
| author_sort | Wenzai Shi |
| collection | DOAJ |
| description | Abstract The “Life’s Essential 8” (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk by optimizing lifestyle factors including diet, physical activity, and other health metrics. While individual components of LE8 have been linked to reduced cancer risks, comprehensive studies on LE8 score trajectories over time and their relation to cancer risk are lacking. This study employed the Kailuan cohort, involving 48,330 participants who underwent three health examinations from 2006 to 2010 to determine their LE8 scores. LE8 score trajectories were analyzed using latent mixture modeling, and their association with incident cancer risks was assessed through Cox proportional hazard models, adjusting for confounders such as age, biological sex, and lifestyle behaviors. Three distinct LE8 trajectory patterns were identified: low-stable (21.2%), moderate-stable (49.4%), and elevated-stable (29.4%). Participants with elevated-stable trajectories showed a 21% (HR = 0.79; 95% CI: 0.70–0.90), 27% (HR = 0.73, 95% CI: 0.57–0.92), 51% (HR = 0.49, 95% CI: 0.32–0.77), 31% (HR = 0.69, 95% CI: 0.50–0.97) and 39% (HR = 0.61, 95% CI: 0.39–0.95) reduction in overall, lung, breast, colorectal and liver cancer risk compared to those with low-stable scores. Notably, the protective effect of elevated-stable LE8 scores against breast cancer was pronounced in participants with elevated CRP levels, indicating an interaction between inflammation and LE8 trajectories. Maintaining high and stable LE8 scores significantly associated with reduced cancer risk, underscoring the importance of integrating LE8 into public health and clinical strategies for cancer prevention. Kailuan study, ChiCTR–TNRC–11,001,489. Registered August 24, 2011-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=8050 . |
| format | Article |
| id | doaj-art-5146aa33beb34d48917a9684e1913528 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-5146aa33beb34d48917a9684e19135282025-08-20T02:41:33ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-94009-xThe association of life’s essential 8 scores trajectory patterns with the risk of all cancer typesWenzai Shi0Yiming Wang1Shuohua Chen2Pengcheng Wei3Delin Ma4Jiye Zhu5Qingsong Zhang6Zhao Li7Department of Hepatobiliary Surgery, Peking University International HospitalDepartment of Hepatological Surgery, Kailuan General HospitalDepartment of Cardiology, Kailuan General HospitalDepartment of Hepatobiliary Surgery, Peking University People’s HospitalDepartment of Hepatobiliary Surgery, Peking University People’s HospitalDepartment of Hepatobiliary Surgery, Peking University People’s HospitalDepartment of General Surgery, Kailuan General HospitalDepartment of Hepatobiliary Surgery, Peking University People’s HospitalAbstract The “Life’s Essential 8” (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk by optimizing lifestyle factors including diet, physical activity, and other health metrics. While individual components of LE8 have been linked to reduced cancer risks, comprehensive studies on LE8 score trajectories over time and their relation to cancer risk are lacking. This study employed the Kailuan cohort, involving 48,330 participants who underwent three health examinations from 2006 to 2010 to determine their LE8 scores. LE8 score trajectories were analyzed using latent mixture modeling, and their association with incident cancer risks was assessed through Cox proportional hazard models, adjusting for confounders such as age, biological sex, and lifestyle behaviors. Three distinct LE8 trajectory patterns were identified: low-stable (21.2%), moderate-stable (49.4%), and elevated-stable (29.4%). Participants with elevated-stable trajectories showed a 21% (HR = 0.79; 95% CI: 0.70–0.90), 27% (HR = 0.73, 95% CI: 0.57–0.92), 51% (HR = 0.49, 95% CI: 0.32–0.77), 31% (HR = 0.69, 95% CI: 0.50–0.97) and 39% (HR = 0.61, 95% CI: 0.39–0.95) reduction in overall, lung, breast, colorectal and liver cancer risk compared to those with low-stable scores. Notably, the protective effect of elevated-stable LE8 scores against breast cancer was pronounced in participants with elevated CRP levels, indicating an interaction between inflammation and LE8 trajectories. Maintaining high and stable LE8 scores significantly associated with reduced cancer risk, underscoring the importance of integrating LE8 into public health and clinical strategies for cancer prevention. Kailuan study, ChiCTR–TNRC–11,001,489. Registered August 24, 2011-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=8050 .https://doi.org/10.1038/s41598-025-94009-xLife’s essential 8CancerTrajectoryProspective |
| spellingShingle | Wenzai Shi Yiming Wang Shuohua Chen Pengcheng Wei Delin Ma Jiye Zhu Qingsong Zhang Zhao Li The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types Scientific Reports Life’s essential 8 Cancer Trajectory Prospective |
| title | The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types |
| title_full | The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types |
| title_fullStr | The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types |
| title_full_unstemmed | The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types |
| title_short | The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types |
| title_sort | association of life s essential 8 scores trajectory patterns with the risk of all cancer types |
| topic | Life’s essential 8 Cancer Trajectory Prospective |
| url | https://doi.org/10.1038/s41598-025-94009-x |
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