Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry
Background Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real‐world data might improve patient selectio...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.037070 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850123548358606848 |
|---|---|
| author | Antonio Sisinni Manuel Barreiro‐Perez Xavier Freixa Dabit Arzamendi Vanessa Moñivas Fernando Carrasco‐Chinchilla Manuel Pan Luis Nombela‐Franco Isaac Pascual Tomás Benito‐González Ruth Perez Iván Gómez‐Blázquez Ignacio J. Amat‐Santos Ignacio Cruz‐González Ángel Sánchez‐Recalde Ana Belén Cid Alvarez Laura Sanchis Berenice Caneiro‐Queija Chi Hion Li Maria del Trigo Jose David Martínez‐Carmona Dolores Mesa Eduardo Pozo Pablo Avanzas Pedro Cepas‐Guillén Rodrigo Estévez‐Loureiro |
| author_facet | Antonio Sisinni Manuel Barreiro‐Perez Xavier Freixa Dabit Arzamendi Vanessa Moñivas Fernando Carrasco‐Chinchilla Manuel Pan Luis Nombela‐Franco Isaac Pascual Tomás Benito‐González Ruth Perez Iván Gómez‐Blázquez Ignacio J. Amat‐Santos Ignacio Cruz‐González Ángel Sánchez‐Recalde Ana Belén Cid Alvarez Laura Sanchis Berenice Caneiro‐Queija Chi Hion Li Maria del Trigo Jose David Martínez‐Carmona Dolores Mesa Eduardo Pozo Pablo Avanzas Pedro Cepas‐Guillén Rodrigo Estévez‐Loureiro |
| author_sort | Antonio Sisinni |
| collection | DOAJ |
| description | Background Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real‐world data might improve patient selection and outcome. The authors sought to investigate acute and short‐term cardiovascular outcomes of tricuspid transcatheter edge‐to‐edge repair (T‐TEER) with dedicated devices in a real‐world setting. Methods and Results This is a retrospective, single‐arm, multicenter registry conducted at 15 sites in Spain. The primary end point was a composite of all‐cause death, rehospitalization for heart failure, and tricuspid valve re‐intervention. Patients included (n=283) were older (76±9 years, 70% female), and showed significant comorbidities. Massive or torrential TR was present in 55% of subjects, with secondary cause being the main mechanism of regurgitation in ≈80% of individuals. Intraprocedural success was achieved in 79% of patients. At 1‐year follow‐up, significant improvements in TR grade (≥3+, 100% to 25%, P <0.001) and New York Heart Association functional class (I/II, 33%–86%, P <0.001) were observed. Lead‐induced cause and single leaflet device attachment emerged as independent predictors of at least severe predischarge residual TR. In‐hospital mortality occurred in 4 (1.4%) patients, whereas the Kaplan–Meier estimated 1‐year primary end point occurrence rate was 21%. Intraprocedural success (hazard ratio, 0.353 [95% CI, 0.156–0.798]; P=0.012), was found to be an independent predictor of primary end point. Conclusions In a real‐world contemporary setting, tricuspid transcatheter edge‐to‐edge repair with dedicated devices emerged as effective therapeutic option for patients with severe TR. |
| format | Article |
| id | doaj-art-5145ee9b67fa47f09c18314b3f6b07ff |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-5145ee9b67fa47f09c18314b3f6b07ff2025-08-20T02:34:35ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-01-0114210.1161/JAHA.124.037070Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain RegistryAntonio Sisinni0Manuel Barreiro‐Perez1Xavier Freixa2Dabit Arzamendi3Vanessa Moñivas4Fernando Carrasco‐Chinchilla5Manuel Pan6Luis Nombela‐Franco7Isaac Pascual8Tomás Benito‐González9Ruth Perez10Iván Gómez‐Blázquez11Ignacio J. Amat‐Santos12Ignacio Cruz‐González13Ángel Sánchez‐Recalde14Ana Belén Cid Alvarez15Laura Sanchis16Berenice Caneiro‐Queija17Chi Hion Li18Maria del Trigo19Jose David Martínez‐Carmona20Dolores Mesa21Eduardo Pozo22Pablo Avanzas23Pedro Cepas‐Guillén24Rodrigo Estévez‐Loureiro25Department of Cardiology University Hospital Alvaro Cunqueiro Vigo SpainDepartment of Cardiology University Hospital Alvaro Cunqueiro Vigo SpainDepartment of Cardiology Cardiovascular Institute, Hospital Clínic Barcelona SpainDivision of Interventional Cardiology Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona Barcelona SpainDepartment of Cardiology University Hospital Puerta de Hierro‐Majadahonda Madrid SpainUnidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, CIBERCV Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA) Málaga SpainDepartment of Cardiology, Hospital Reina Sofía Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC) Córdoba SpainCardiovascular Institute, Hospital Clínico San Carlos IdISSC Madrid SpainHeart Area Hospital Universitario Central de Asturias Oviedo SpainDepartment of Cardiology University Hospital of León León SpainDepartment of Cardiology University Hospital A Coruña SpainDepartment of Cardiology University Hospital 12 Octubre Madrid SpainDepartment of Cardiology University Clinic Hospital, CIBERCV Valladolid SpainDepartment of Cardiology Hospital Universitario de Salamanca, CIBERCV, IBSAL Salamanca SpainDepartment of Cardiology Hospital Universitario Ramón y Cajal Madrid SpainDepartment of Cardiology University Clinic Hospital, CIBERCV Santiago de Compostela SpainDepartment of Cardiology Cardiovascular Institute, Hospital Clínic Barcelona SpainDepartment of Cardiology University Hospital Alvaro Cunqueiro Vigo SpainDivision of Interventional Cardiology Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona Barcelona SpainDepartment of Cardiology University Hospital Puerta de Hierro‐Majadahonda Madrid SpainUnidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, CIBERCV Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA) Málaga SpainDepartment of Cardiology, Hospital Reina Sofía Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC) Córdoba SpainCardiovascular Institute, Hospital Clínico San Carlos IdISSC Madrid SpainHeart Area Hospital Universitario Central de Asturias Oviedo SpainDepartment of Cardiology Cardiovascular Institute, Hospital Clínic Barcelona SpainDepartment of Cardiology University Hospital Alvaro Cunqueiro Vigo SpainBackground Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real‐world data might improve patient selection and outcome. The authors sought to investigate acute and short‐term cardiovascular outcomes of tricuspid transcatheter edge‐to‐edge repair (T‐TEER) with dedicated devices in a real‐world setting. Methods and Results This is a retrospective, single‐arm, multicenter registry conducted at 15 sites in Spain. The primary end point was a composite of all‐cause death, rehospitalization for heart failure, and tricuspid valve re‐intervention. Patients included (n=283) were older (76±9 years, 70% female), and showed significant comorbidities. Massive or torrential TR was present in 55% of subjects, with secondary cause being the main mechanism of regurgitation in ≈80% of individuals. Intraprocedural success was achieved in 79% of patients. At 1‐year follow‐up, significant improvements in TR grade (≥3+, 100% to 25%, P <0.001) and New York Heart Association functional class (I/II, 33%–86%, P <0.001) were observed. Lead‐induced cause and single leaflet device attachment emerged as independent predictors of at least severe predischarge residual TR. In‐hospital mortality occurred in 4 (1.4%) patients, whereas the Kaplan–Meier estimated 1‐year primary end point occurrence rate was 21%. Intraprocedural success (hazard ratio, 0.353 [95% CI, 0.156–0.798]; P=0.012), was found to be an independent predictor of primary end point. Conclusions In a real‐world contemporary setting, tricuspid transcatheter edge‐to‐edge repair with dedicated devices emerged as effective therapeutic option for patients with severe TR.https://www.ahajournals.org/doi/10.1161/JAHA.124.037070edge‐to‐edge repairprocedural successtranscatheter treatmenttricuspid regurgitationTRI‐SPA |
| spellingShingle | Antonio Sisinni Manuel Barreiro‐Perez Xavier Freixa Dabit Arzamendi Vanessa Moñivas Fernando Carrasco‐Chinchilla Manuel Pan Luis Nombela‐Franco Isaac Pascual Tomás Benito‐González Ruth Perez Iván Gómez‐Blázquez Ignacio J. Amat‐Santos Ignacio Cruz‐González Ángel Sánchez‐Recalde Ana Belén Cid Alvarez Laura Sanchis Berenice Caneiro‐Queija Chi Hion Li Maria del Trigo Jose David Martínez‐Carmona Dolores Mesa Eduardo Pozo Pablo Avanzas Pedro Cepas‐Guillén Rodrigo Estévez‐Loureiro Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease edge‐to‐edge repair procedural success transcatheter treatment tricuspid regurgitation TRI‐SPA |
| title | Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry |
| title_full | Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry |
| title_fullStr | Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry |
| title_full_unstemmed | Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry |
| title_short | Real‐World Experience in Tricuspid Transcatheter Edge‐to‐Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry |
| title_sort | real world experience in tricuspid transcatheter edge to edge repair transcatheter tricuspid valve repair in spain registry |
| topic | edge‐to‐edge repair procedural success transcatheter treatment tricuspid regurgitation TRI‐SPA |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.037070 |
| work_keys_str_mv | AT antoniosisinni realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT manuelbarreiroperez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT xavierfreixa realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT dabitarzamendi realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT vanessamonivas realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT fernandocarrascochinchilla realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT manuelpan realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT luisnombelafranco realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT isaacpascual realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT tomasbenitogonzalez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT ruthperez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT ivangomezblazquez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT ignaciojamatsantos realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT ignaciocruzgonzalez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT angelsanchezrecalde realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT anabelencidalvarez realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT laurasanchis realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT berenicecaneiroqueija realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT chihionli realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT mariadeltrigo realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT josedavidmartinezcarmona realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT doloresmesa realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT eduardopozo realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT pabloavanzas realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT pedrocepasguillen realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry AT rodrigoestevezloureiro realworldexperienceintricuspidtranscatheteredgetoedgerepairtranscathetertricuspidvalverepairinspainregistry |