Desmosomes In Vivo
The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, cal...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/212439 |
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| author | David Garrod |
| author_facet | David Garrod |
| author_sort | David Garrod |
| collection | DOAJ |
| description | The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium-dependent desmosomes, although hyperadhesion can be readily obtained in confluent cell culture. Calcium dependence is a default condition in vivo, found in wounds and embryonic development. Hyperadhesion appears to be associated with an ordered arrangement of the extracellular domains of the desmosomal cadherins, which gives rise to the intercellular midline identified in ultrastructural studies. This in turn probably depends on molecular order in the desmosomal plaque. Protein kinase C downregulates hyperadhesion and there is preliminary evidence that it may also be regulated by tyrosine kinases. Downregulation of desmosomes in vivo may occur by internalisation of whole desmosomes rather than disassembly. Hyperadhesion has implications for diseases such as pemphigus. |
| format | Article |
| id | doaj-art-5140cf8f59ba4647b1826188ea72bf52 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-5140cf8f59ba4647b1826188ea72bf522025-02-03T06:10:49ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/212439212439Desmosomes In VivoDavid Garrod0Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UKThe structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium-dependent desmosomes, although hyperadhesion can be readily obtained in confluent cell culture. Calcium dependence is a default condition in vivo, found in wounds and embryonic development. Hyperadhesion appears to be associated with an ordered arrangement of the extracellular domains of the desmosomal cadherins, which gives rise to the intercellular midline identified in ultrastructural studies. This in turn probably depends on molecular order in the desmosomal plaque. Protein kinase C downregulates hyperadhesion and there is preliminary evidence that it may also be regulated by tyrosine kinases. Downregulation of desmosomes in vivo may occur by internalisation of whole desmosomes rather than disassembly. Hyperadhesion has implications for diseases such as pemphigus.http://dx.doi.org/10.1155/2010/212439 |
| spellingShingle | David Garrod Desmosomes In Vivo Dermatology Research and Practice |
| title | Desmosomes In Vivo |
| title_full | Desmosomes In Vivo |
| title_fullStr | Desmosomes In Vivo |
| title_full_unstemmed | Desmosomes In Vivo |
| title_short | Desmosomes In Vivo |
| title_sort | desmosomes in vivo |
| url | http://dx.doi.org/10.1155/2010/212439 |
| work_keys_str_mv | AT davidgarrod desmosomesinvivo |