Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study
Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the...
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Shahid Sadoughi University of Medical Sciences and Health Services
2025-02-01
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| Series: | Journal of Nutrition and Food Security |
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| Online Access: | http://jnfs.ssu.ac.ir/article-1-1071-en.pdf |
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| author | Saba Narmcheshm Fatemeh Toorang Bahareh Sasanfar Maryam Hadji Ahmadreza Dorosty Motlagh Kazem Zendehdel |
| author_facet | Saba Narmcheshm Fatemeh Toorang Bahareh Sasanfar Maryam Hadji Ahmadreza Dorosty Motlagh Kazem Zendehdel |
| author_sort | Saba Narmcheshm |
| collection | DOAJ |
| description | Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the Iranian population's GC risk. Methods: In total, 178 newly diagnosed GC patients and 238 healthy controls were recruited for this hospital-based case-control study. Dietary intakes were collected using a validated 146-item diet history questionnaire (DHQ), and dTAC was analyzed using Ferric reducing antioxidant potential (FRAP) assay. Results: The mean value of dTAC was 10.42±5.42 for cases and 11.42±5.86 for controls. Black tea, fruits, and cereals consumption were the main contributors to dTAC in both groups. DTAC was associated with a reduction in the risk of GC (OR 0.54; 95%CI: 0.31–0.92) (second vs. lowest tertile). This association did not change after adjustment for body mass index, education, energy intake, smoking, and Helicobacter pylori infection (0.55; 95% CI: 0.31-0.99). There was no significant association between fruits, vegetables, nuts, and legumes TAC with GC. Conclusion: The whole intake of dTAC from different food sources was not high in the population; however, this amount showed a preventive effect against GC. |
| format | Article |
| id | doaj-art-513a77684d0a4be4a6c23efb15402c46 |
| institution | Kabale University |
| issn | 2476-7417 2476-7425 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
| record_format | Article |
| series | Journal of Nutrition and Food Security |
| spelling | doaj-art-513a77684d0a4be4a6c23efb15402c462025-02-08T10:57:36ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252025-02-011011522Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control StudySaba Narmcheshm0Fatemeh Toorang1Bahareh Sasanfar2Maryam Hadji3Ahmadreza Dorosty Motlagh4Kazem Zendehdel5 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Departments of Medical and Surgical Sciences, University of Bologna, Italy Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70150, Finland Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the Iranian population's GC risk. Methods: In total, 178 newly diagnosed GC patients and 238 healthy controls were recruited for this hospital-based case-control study. Dietary intakes were collected using a validated 146-item diet history questionnaire (DHQ), and dTAC was analyzed using Ferric reducing antioxidant potential (FRAP) assay. Results: The mean value of dTAC was 10.42±5.42 for cases and 11.42±5.86 for controls. Black tea, fruits, and cereals consumption were the main contributors to dTAC in both groups. DTAC was associated with a reduction in the risk of GC (OR 0.54; 95%CI: 0.31–0.92) (second vs. lowest tertile). This association did not change after adjustment for body mass index, education, energy intake, smoking, and Helicobacter pylori infection (0.55; 95% CI: 0.31-0.99). There was no significant association between fruits, vegetables, nuts, and legumes TAC with GC. Conclusion: The whole intake of dTAC from different food sources was not high in the population; however, this amount showed a preventive effect against GC.http://jnfs.ssu.ac.ir/article-1-1071-en.pdfcase-controldietfrapstomach neoplasmstotal antioxidant capacity. |
| spellingShingle | Saba Narmcheshm Fatemeh Toorang Bahareh Sasanfar Maryam Hadji Ahmadreza Dorosty Motlagh Kazem Zendehdel Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study Journal of Nutrition and Food Security case-control diet frap stomach neoplasms total antioxidant capacity. |
| title | Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study |
| title_full | Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study |
| title_fullStr | Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study |
| title_full_unstemmed | Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study |
| title_short | Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study |
| title_sort | dietary total antioxidant capacity and gastric cancer a case control study |
| topic | case-control diet frap stomach neoplasms total antioxidant capacity. |
| url | http://jnfs.ssu.ac.ir/article-1-1071-en.pdf |
| work_keys_str_mv | AT sabanarmcheshm dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy AT fatemehtoorang dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy AT baharehsasanfar dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy AT maryamhadji dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy AT ahmadrezadorostymotlagh dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy AT kazemzendehdel dietarytotalantioxidantcapacityandgastriccanceracasecontrolstudy |