Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach
<b>Background/Objectives:</b> Type 2 diabetes mellitus (T2DM) is a metabolic disease whose importance rises with aging, though it is also looming large in younger populations due to increasing obesity. Its effects may damage renal and heart functioning. Plasma biomarkers of T2DM have bee...
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2025-06-01
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| author | Alba Simón Daniel Bordonaba-Bosque Olimpio Montero Javier Solano-Castán Irma Caro |
| author_facet | Alba Simón Daniel Bordonaba-Bosque Olimpio Montero Javier Solano-Castán Irma Caro |
| author_sort | Alba Simón |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Type 2 diabetes mellitus (T2DM) is a metabolic disease whose importance rises with aging, though it is also looming large in younger populations due to increasing obesity. Its effects may damage renal and heart functioning. Plasma biomarkers of T2DM have been shown through metabolomic studies under different conditions, mainly obesity, but untargeted metabolomic studies on T2DM are lacking for elderly people. <b>Methods:</b> A UPLC-MS-based metabolomic approach was conducted to ascertain potential plasma biomarkers in a cohort older than 65 years. <b>Results:</b> The dipeptide Gly-His, along with diverse lysophosphatidylcholines (LPCs), mainly LPC(14:0) and LPC(20:4), and three gangliosides were found to have different plasma content in T2DM subjects compared to control (non-diabetic) subjects (NT2DM). LPC(20:4) exhibited a gender dependence, with statistically significant differences only in females. Gly-His correlated with MEDAS-14, whereas LPC(14:0) correlated with sugar-rich food consumption. <b>Conclusions:</b> As previously demonstrated for other conditions, mainly obesity, altered lipid metabolism was shown in this study to be a hallmark of T2DM in elderly people also. |
| format | Article |
| id | doaj-art-51355fc604b34eff8a53ef7bef92055f |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Metabolites |
| spelling | doaj-art-51355fc604b34eff8a53ef7bef92055f2025-08-20T02:21:14ZengMDPI AGMetabolites2218-19892025-06-0115639510.3390/metabo15060395Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic ApproachAlba Simón0Daniel Bordonaba-Bosque1Olimpio Montero2Javier Solano-Castán3Irma Caro4Centro de Salud de Almudevar, Servicio Aragonés de Salud, 22270 Huesca, SpainServicio de Apoyo Metodológico, Estadístico y Documental (SAMEyD), Instituto Aragonés de Ciencias de la Salud (IACS), Avda. San Juan Bosco, 13, 50009 Zaragoza, SpainUnidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), 47003 Valladolid, SpainMáster en Nutrición Geriátrica, Departamento de Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia, Universidad de Valladolid, 47005 Valladolid, SpainMáster en Nutrición Geriátrica, Departamento de Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia, Universidad de Valladolid, 47005 Valladolid, Spain<b>Background/Objectives:</b> Type 2 diabetes mellitus (T2DM) is a metabolic disease whose importance rises with aging, though it is also looming large in younger populations due to increasing obesity. Its effects may damage renal and heart functioning. Plasma biomarkers of T2DM have been shown through metabolomic studies under different conditions, mainly obesity, but untargeted metabolomic studies on T2DM are lacking for elderly people. <b>Methods:</b> A UPLC-MS-based metabolomic approach was conducted to ascertain potential plasma biomarkers in a cohort older than 65 years. <b>Results:</b> The dipeptide Gly-His, along with diverse lysophosphatidylcholines (LPCs), mainly LPC(14:0) and LPC(20:4), and three gangliosides were found to have different plasma content in T2DM subjects compared to control (non-diabetic) subjects (NT2DM). LPC(20:4) exhibited a gender dependence, with statistically significant differences only in females. Gly-His correlated with MEDAS-14, whereas LPC(14:0) correlated with sugar-rich food consumption. <b>Conclusions:</b> As previously demonstrated for other conditions, mainly obesity, altered lipid metabolism was shown in this study to be a hallmark of T2DM in elderly people also.https://www.mdpi.com/2218-1989/15/6/395diabetes mellitus type 2elderly peoplemetabolomicsdietUPLC-MS |
| spellingShingle | Alba Simón Daniel Bordonaba-Bosque Olimpio Montero Javier Solano-Castán Irma Caro Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach Metabolites diabetes mellitus type 2 elderly people metabolomics diet UPLC-MS |
| title | Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach |
| title_full | Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach |
| title_fullStr | Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach |
| title_full_unstemmed | Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach |
| title_short | Blood Metabolic Biomarkers of Diabetes Mellitus Type 2 in Aged Adults Determined by a UPLC-MS Metabolomic Approach |
| title_sort | blood metabolic biomarkers of diabetes mellitus type 2 in aged adults determined by a uplc ms metabolomic approach |
| topic | diabetes mellitus type 2 elderly people metabolomics diet UPLC-MS |
| url | https://www.mdpi.com/2218-1989/15/6/395 |
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