Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia
Abstract Objectives Achalasia is an esophageal motility disorder of unknown etiology. However, no studies have determined the populations in which sleep problems occur and whether they are improved by peroral endoscopic myotomy (POEM). We investigated the rate of sleep problems assessed by GERD‐Q (A...
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/deo2.70064 |
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| author | Toshihiro Ohmiya Hironari Shiwaku Hiroki Okada Akio Shiwaku Suguru Hasegawa |
| author_facet | Toshihiro Ohmiya Hironari Shiwaku Hiroki Okada Akio Shiwaku Suguru Hasegawa |
| author_sort | Toshihiro Ohmiya |
| collection | DOAJ |
| description | Abstract Objectives Achalasia is an esophageal motility disorder of unknown etiology. However, no studies have determined the populations in which sleep problems occur and whether they are improved by peroral endoscopic myotomy (POEM). We investigated the rate of sleep problems assessed by GERD‐Q (AGQ) in achalasia patients, evaluated whether POEM improves these issues, and identified factors associated with sleep improvement after POEM. Methods We retrospectively analyzed the data of patients who were diagnosed with achalasia and who underwent POEM at a single institution between March 2016 and December 2020. We examined the Eckardt symptom score and the GERD‐Q before and 3 months after POEM to assess the presence of sleep problems (AGQ) and other symptoms. The univariate logistic regression analysis was performed to identify factors associated with sleep problem (AGQ) improvement after POEM. Results A total of 177 patients were included. The average age was 52.6 ± 17.2 years. Preoperatively, dysphagia (172 [97.2%]), regurgitation (123 [69.5%]), sleep problems (AGQ; 110 [62.1%]), chest pain (102 [57.6%]), and weight loss (83 [46.9%]) were observed. Before POEM, 62.1% of patients experienced sleep problems (AGQ) compared with 9.6% after POEM (p < 0.0001). Postoperative dysphagia and regurgitation were significant factors determining whether patients continued to experience sleep problems (AGQ) after POEM. Conclusions Sleep problems (AGQ) were the third most common symptom in > 60% of patients with achalasia. Improving dysphagia and regurgitation using the POEM procedure improved sleep problems (AGQ). |
| format | Article |
| id | doaj-art-5134971704f94ebfa6cfd9be97d4693c |
| institution | OA Journals |
| issn | 2692-4609 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-5134971704f94ebfa6cfd9be97d4693c2025-08-20T02:18:56ZengWileyDEN Open2692-46092025-04-0151n/an/a10.1002/deo2.70064Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasiaToshihiro Ohmiya0Hironari Shiwaku1Hiroki Okada2Akio Shiwaku3Suguru Hasegawa4Department of Gastroenterological Surgery Fukuoka University Faculty of Medicine Fukuoka JapanDepartment of Gastroenterological Surgery Fukuoka University Faculty of Medicine Fukuoka JapanDepartment of Gastroenterological Surgery Fukuoka University Faculty of Medicine Fukuoka JapanDepartment of Gastroenterological Surgery Fukuoka University Faculty of Medicine Fukuoka JapanDepartment of Gastroenterological Surgery Fukuoka University Faculty of Medicine Fukuoka JapanAbstract Objectives Achalasia is an esophageal motility disorder of unknown etiology. However, no studies have determined the populations in which sleep problems occur and whether they are improved by peroral endoscopic myotomy (POEM). We investigated the rate of sleep problems assessed by GERD‐Q (AGQ) in achalasia patients, evaluated whether POEM improves these issues, and identified factors associated with sleep improvement after POEM. Methods We retrospectively analyzed the data of patients who were diagnosed with achalasia and who underwent POEM at a single institution between March 2016 and December 2020. We examined the Eckardt symptom score and the GERD‐Q before and 3 months after POEM to assess the presence of sleep problems (AGQ) and other symptoms. The univariate logistic regression analysis was performed to identify factors associated with sleep problem (AGQ) improvement after POEM. Results A total of 177 patients were included. The average age was 52.6 ± 17.2 years. Preoperatively, dysphagia (172 [97.2%]), regurgitation (123 [69.5%]), sleep problems (AGQ; 110 [62.1%]), chest pain (102 [57.6%]), and weight loss (83 [46.9%]) were observed. Before POEM, 62.1% of patients experienced sleep problems (AGQ) compared with 9.6% after POEM (p < 0.0001). Postoperative dysphagia and regurgitation were significant factors determining whether patients continued to experience sleep problems (AGQ) after POEM. Conclusions Sleep problems (AGQ) were the third most common symptom in > 60% of patients with achalasia. Improving dysphagia and regurgitation using the POEM procedure improved sleep problems (AGQ).https://doi.org/10.1002/deo2.70064achalasiagastroesophageal reflux diseaseperoral endoscopic myotomyquality of lifesleep problem |
| spellingShingle | Toshihiro Ohmiya Hironari Shiwaku Hiroki Okada Akio Shiwaku Suguru Hasegawa Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia DEN Open achalasia gastroesophageal reflux disease peroral endoscopic myotomy quality of life sleep problem |
| title | Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| title_full | Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| title_fullStr | Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| title_full_unstemmed | Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| title_short | Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| title_sort | efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia |
| topic | achalasia gastroesophageal reflux disease peroral endoscopic myotomy quality of life sleep problem |
| url | https://doi.org/10.1002/deo2.70064 |
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