Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications
Bone plates are essential for bone fracture healing because they modify the biomechanical microenvironment at the fracture site to provide the necessary mechanical fixation for fracture fragments. The objective of this study was to determine cell availability, antibacterial activity, and wettability...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2023/4219841 |
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| author | Tamara R. Kadhim Jawad K. Oleiwi Qahtan A. Hamad |
| author_facet | Tamara R. Kadhim Jawad K. Oleiwi Qahtan A. Hamad |
| author_sort | Tamara R. Kadhim |
| collection | DOAJ |
| description | Bone plates are essential for bone fracture healing because they modify the biomechanical microenvironment at the fracture site to provide the necessary mechanical fixation for fracture fragments. The objective of this study was to determine cell availability, antibacterial activity, and wettability through a contact angle test. However, biocomposites that involve UHMWPE reinforced with n-HA and n-TiO2 particles at different fractions (0, 1.5, 2.5, 3.5, and 4.5%) and 5% from carbon and Kevlar fibers were fabricated by hot pressing technique. In vitro studies revealed good cell viability on the surface of the hybrid biocomposite even after 72 hr. The UHMEPE nanocomposite reinforced with carbon showed better cell attachment for fibroblasts than other UHMWPE nanocomposite materials reinforced with Kevlar fiber. The results of the contact angle measurements indicated that the incorporation of nanoparticles and the fiber reinforcement increased the wettability due to the hydrophilic character of nanobiocomposite, and also (UHMWPE-4.5% wt. TiO2–CF) biocomposite was the best wettability (∼48% as compared to neat UHMWPE). Antibacterial experiments involving Gram-positive bacteria, Staphylococcus aureus, confirm excellent bactericidal property for (UHMWPE-4.5% wt. TiO2–CF) biocomposite. Thermal analysis of the produced nanocomposites revealed that they had higher melting and crystallinity temperatures than pure UHMWPE. |
| format | Article |
| id | doaj-art-5132ea0b18e040febdd66e838e371878 |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-5132ea0b18e040febdd66e838e3718782025-08-20T03:36:37ZengWileyInternational Journal of Biomaterials1687-87952023-01-01202310.1155/2023/4219841Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic ApplicationsTamara R. Kadhim0Jawad K. Oleiwi1Qahtan A. Hamad2Materials Engineering DepartmentMaterials Engineering DepartmentMaterials Engineering DepartmentBone plates are essential for bone fracture healing because they modify the biomechanical microenvironment at the fracture site to provide the necessary mechanical fixation for fracture fragments. The objective of this study was to determine cell availability, antibacterial activity, and wettability through a contact angle test. However, biocomposites that involve UHMWPE reinforced with n-HA and n-TiO2 particles at different fractions (0, 1.5, 2.5, 3.5, and 4.5%) and 5% from carbon and Kevlar fibers were fabricated by hot pressing technique. In vitro studies revealed good cell viability on the surface of the hybrid biocomposite even after 72 hr. The UHMEPE nanocomposite reinforced with carbon showed better cell attachment for fibroblasts than other UHMWPE nanocomposite materials reinforced with Kevlar fiber. The results of the contact angle measurements indicated that the incorporation of nanoparticles and the fiber reinforcement increased the wettability due to the hydrophilic character of nanobiocomposite, and also (UHMWPE-4.5% wt. TiO2–CF) biocomposite was the best wettability (∼48% as compared to neat UHMWPE). Antibacterial experiments involving Gram-positive bacteria, Staphylococcus aureus, confirm excellent bactericidal property for (UHMWPE-4.5% wt. TiO2–CF) biocomposite. Thermal analysis of the produced nanocomposites revealed that they had higher melting and crystallinity temperatures than pure UHMWPE.http://dx.doi.org/10.1155/2023/4219841 |
| spellingShingle | Tamara R. Kadhim Jawad K. Oleiwi Qahtan A. Hamad Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications International Journal of Biomaterials |
| title | Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications |
| title_full | Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications |
| title_fullStr | Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications |
| title_full_unstemmed | Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications |
| title_short | Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications |
| title_sort | improving the biological properties of uhmwpe biocomposite for orthopedic applications |
| url | http://dx.doi.org/10.1155/2023/4219841 |
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