Diabetic cardiomyopathy: merely a complication or a distinct understudied disease?
Since the 1970s, researchers have investigated a specific disorder of myocardial structure and function in diabetes mellitus (DM) — diabetic cardiomyopathy (DC) – whose primary clinical manifestation is heart failure (HF). Numerous studies demonstrate a high risk of HF in patients with type 2 diabet...
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Столичная издательская компания
2025-08-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/3150 |
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| author | B. U. Mardanov M. N. Mamedov |
| author_facet | B. U. Mardanov M. N. Mamedov |
| author_sort | B. U. Mardanov |
| collection | DOAJ |
| description | Since the 1970s, researchers have investigated a specific disorder of myocardial structure and function in diabetes mellitus (DM) — diabetic cardiomyopathy (DC) – whose primary clinical manifestation is heart failure (HF). Numerous studies demonstrate a high risk of HF in patients with type 2 diabetes mellitus (T2DM), alongside worsened prognosis when these conditions coexist. For instance, the Kaiser Permanente population study demonstrated a 3- to 4-fold higher HF risk in T2DM patients under 75 years compared to non-diabetic individuals. Despite accumulated research, DCM remains classified by many experts as a complication of DM rather than a distinct entity, fueling ongoing discussion. At the same time, ongoing studies increasingly reveal characteristic disorders of heart function with pathophysiological features, suggesting that DCM may constitute a separate condition occurring within the diabetic context. To date, there are no generally accepted clinical guidelines for DCM diagnosis and management, and therefore there is a need for standardized diagnostic criteria to identify high-risk populations. The review analyzes current literature data on terminology, etiology, pathogenesis, and treatment. Systematisation of existing knowledge and clear diagnostic criteria would facilitate greater focus on novel treatment strategies. |
| format | Article |
| id | doaj-art-5130ce50e1c74a6f87a8557c83066028 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-5130ce50e1c74a6f87a8557c830660282025-08-23T10:00:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532025-08-0121329830610.20996/1819-6446-2025-31502292Diabetic cardiomyopathy: merely a complication or a distinct understudied disease?B. U. Mardanov0M. N. Mamedov1National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineSince the 1970s, researchers have investigated a specific disorder of myocardial structure and function in diabetes mellitus (DM) — diabetic cardiomyopathy (DC) – whose primary clinical manifestation is heart failure (HF). Numerous studies demonstrate a high risk of HF in patients with type 2 diabetes mellitus (T2DM), alongside worsened prognosis when these conditions coexist. For instance, the Kaiser Permanente population study demonstrated a 3- to 4-fold higher HF risk in T2DM patients under 75 years compared to non-diabetic individuals. Despite accumulated research, DCM remains classified by many experts as a complication of DM rather than a distinct entity, fueling ongoing discussion. At the same time, ongoing studies increasingly reveal characteristic disorders of heart function with pathophysiological features, suggesting that DCM may constitute a separate condition occurring within the diabetic context. To date, there are no generally accepted clinical guidelines for DCM diagnosis and management, and therefore there is a need for standardized diagnostic criteria to identify high-risk populations. The review analyzes current literature data on terminology, etiology, pathogenesis, and treatment. Systematisation of existing knowledge and clear diagnostic criteria would facilitate greater focus on novel treatment strategies.https://www.rpcardio.online/jour/article/view/3150diabetic cardiomyopathyheart failurecardiac autonomic neuropathyinsulin resistanceendothelial dysfunctionhypoglycemic therapysodium-glucose cotransporter 2 inhibitors |
| spellingShingle | B. U. Mardanov M. N. Mamedov Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? Рациональная фармакотерапия в кардиологии diabetic cardiomyopathy heart failure cardiac autonomic neuropathy insulin resistance endothelial dysfunction hypoglycemic therapy sodium-glucose cotransporter 2 inhibitors |
| title | Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? |
| title_full | Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? |
| title_fullStr | Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? |
| title_full_unstemmed | Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? |
| title_short | Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? |
| title_sort | diabetic cardiomyopathy merely a complication or a distinct understudied disease |
| topic | diabetic cardiomyopathy heart failure cardiac autonomic neuropathy insulin resistance endothelial dysfunction hypoglycemic therapy sodium-glucose cotransporter 2 inhibitors |
| url | https://www.rpcardio.online/jour/article/view/3150 |
| work_keys_str_mv | AT bumardanov diabeticcardiomyopathymerelyacomplicationoradistinctunderstudieddisease AT mnmamedov diabeticcardiomyopathymerelyacomplicationoradistinctunderstudieddisease |