The Role of the Mitochondrial Genome in Ageing and Carcinogenesis
Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished whe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/136435 |
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| _version_ | 1850225684227555328 |
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| author | Anna M. Czarnecka Ewa Bartnik |
| author_facet | Anna M. Czarnecka Ewa Bartnik |
| author_sort | Anna M. Czarnecka |
| collection | DOAJ |
| description | Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others. |
| format | Article |
| id | doaj-art-512ac8d0b738438e899260ffa8905595 |
| institution | OA Journals |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-512ac8d0b738438e899260ffa89055952025-08-20T02:05:17ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/136435136435The Role of the Mitochondrial Genome in Ageing and CarcinogenesisAnna M. Czarnecka0Ewa Bartnik1Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 01-141 Warsaw, PolandInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, PolandMitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.http://dx.doi.org/10.4061/2011/136435 |
| spellingShingle | Anna M. Czarnecka Ewa Bartnik The Role of the Mitochondrial Genome in Ageing and Carcinogenesis Journal of Aging Research |
| title | The Role of the Mitochondrial Genome in Ageing and Carcinogenesis |
| title_full | The Role of the Mitochondrial Genome in Ageing and Carcinogenesis |
| title_fullStr | The Role of the Mitochondrial Genome in Ageing and Carcinogenesis |
| title_full_unstemmed | The Role of the Mitochondrial Genome in Ageing and Carcinogenesis |
| title_short | The Role of the Mitochondrial Genome in Ageing and Carcinogenesis |
| title_sort | role of the mitochondrial genome in ageing and carcinogenesis |
| url | http://dx.doi.org/10.4061/2011/136435 |
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