Clinical and laboratory features of enteroviral meningitis course in adults and children
Objective – to determine the frequency of serous meningitis of enteroviral etiology and find out their clinical and laboratory features. Materials and Methods. The study included 51 patients with serous meningitis. To confirm the serous meningitis of enteroviral etiology the method of polymerase...
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Zaporizhzhia State Medical and Pharmaceutical University
2017-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/100893/97176 |
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| author | D. A. Zadiraka E. V. Riabokon E. V. Usacheva A. М. Kamyshny |
| author_facet | D. A. Zadiraka E. V. Riabokon E. V. Usacheva A. М. Kamyshny |
| author_sort | D. A. Zadiraka |
| collection | DOAJ |
| description | Objective – to determine the frequency of serous meningitis of enteroviral etiology and find out their clinical and laboratory features.
Materials and Methods. The study included 51 patients with serous meningitis. To confirm the serous meningitis of enteroviral etiology the method of polymerase chain reaction with enteroviruses RNA identification in feces and cerebrospinal fluid and subsequent identification of the enterovirus type 71. The study has been carried out as a part of an open cohort study of the Small Grants Joint Programme WHO/HHWS focused on the programs of the communicable disease control implementation.
Results. Enterovirus etiology of serous meningitis was confirmed in 27 (52.9 %) patients, but the genotype of enterovirus type 71 was not detected in any case. The risk group of serous meningitis of enteroviral etiology development were children aged 8–11 years, as the frequency of serous meningitis of enteroviral etiology among them was 40.8 % against 12.5 % (χ2 = 5.09, p < 0.02) of cases serous meningitis of unknown etiology in the same age group.
Serous meningitis of enteroviral etiology, which was not caused by virus type 71, was characterized by acute onset, less pronounced cerebral symptomatology, dissociation of meningeal signs (48.1 %), neutrophilic pleocytosis (25.9 %) at the beginning of the disease and benign course of the disease due to faster regress in the clinical manifestations of the disease such as headache and meningeal signs.
Conclusions. Enterovirus etiology of serous meningitis was confirmed in 52.9 % of patients but there was not identification of enterovirus genotype 71. Mostly serous meningitis had enterovirus etiology in children of 8–11 years old. Serous meningitis of enteroviral etiology was not caused by virus type 71, and was characterized by acute onset, less severe cerebral symptoms, dissociation of meningeal signs, neutrophilic pleocytosis at the beginning of the disease and benign course of the disease. |
| format | Article |
| id | doaj-art-512969038e0343c28d0d6113ad2cd5e0 |
| institution | Kabale University |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-512969038e0343c28d0d6113ad2cd5e02025-08-20T03:36:37ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102017-06-013342346http://dx.doi.org/10.14739/2310-1210.2017.3.100893Clinical and laboratory features of enteroviral meningitis course in adults and childrenD. A. ZadirakaE. V. RiabokonE. V. UsachevaA. М. KamyshnyObjective – to determine the frequency of serous meningitis of enteroviral etiology and find out their clinical and laboratory features. Materials and Methods. The study included 51 patients with serous meningitis. To confirm the serous meningitis of enteroviral etiology the method of polymerase chain reaction with enteroviruses RNA identification in feces and cerebrospinal fluid and subsequent identification of the enterovirus type 71. The study has been carried out as a part of an open cohort study of the Small Grants Joint Programme WHO/HHWS focused on the programs of the communicable disease control implementation. Results. Enterovirus etiology of serous meningitis was confirmed in 27 (52.9 %) patients, but the genotype of enterovirus type 71 was not detected in any case. The risk group of serous meningitis of enteroviral etiology development were children aged 8–11 years, as the frequency of serous meningitis of enteroviral etiology among them was 40.8 % against 12.5 % (χ2 = 5.09, p < 0.02) of cases serous meningitis of unknown etiology in the same age group. Serous meningitis of enteroviral etiology, which was not caused by virus type 71, was characterized by acute onset, less pronounced cerebral symptomatology, dissociation of meningeal signs (48.1 %), neutrophilic pleocytosis (25.9 %) at the beginning of the disease and benign course of the disease due to faster regress in the clinical manifestations of the disease such as headache and meningeal signs. Conclusions. Enterovirus etiology of serous meningitis was confirmed in 52.9 % of patients but there was not identification of enterovirus genotype 71. Mostly serous meningitis had enterovirus etiology in children of 8–11 years old. Serous meningitis of enteroviral etiology was not caused by virus type 71, and was characterized by acute onset, less severe cerebral symptoms, dissociation of meningeal signs, neutrophilic pleocytosis at the beginning of the disease and benign course of the disease.http://zmj.zsmu.edu.ua/article/view/100893/97176enterovirus infectionaseptic meningitis |
| spellingShingle | D. A. Zadiraka E. V. Riabokon E. V. Usacheva A. М. Kamyshny Clinical and laboratory features of enteroviral meningitis course in adults and children Zaporožskij Medicinskij Žurnal enterovirus infection aseptic meningitis |
| title | Clinical and laboratory features of enteroviral meningitis course in adults and children |
| title_full | Clinical and laboratory features of enteroviral meningitis course in adults and children |
| title_fullStr | Clinical and laboratory features of enteroviral meningitis course in adults and children |
| title_full_unstemmed | Clinical and laboratory features of enteroviral meningitis course in adults and children |
| title_short | Clinical and laboratory features of enteroviral meningitis course in adults and children |
| title_sort | clinical and laboratory features of enteroviral meningitis course in adults and children |
| topic | enterovirus infection aseptic meningitis |
| url | http://zmj.zsmu.edu.ua/article/view/100893/97176 |
| work_keys_str_mv | AT dazadiraka clinicalandlaboratoryfeaturesofenteroviralmeningitiscourseinadultsandchildren AT evriabokon clinicalandlaboratoryfeaturesofenteroviralmeningitiscourseinadultsandchildren AT evusacheva clinicalandlaboratoryfeaturesofenteroviralmeningitiscourseinadultsandchildren AT amkamyshny clinicalandlaboratoryfeaturesofenteroviralmeningitiscourseinadultsandchildren |